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- W788121028 abstract "The toxic response of two individuals who are exposed to the same dose of a toxicant can be quite different. Can we predict this response if we know the genome or, more importantly, the epigenome of the individual? The genetic variability of an individual provides important information regarding the toxicological response after chemical exposure. This information has led to the development of proposals for new approaches in the treatment of toxic effects based on genetic variation. In addition, studies have shown that both genetic variation and epigenetic variation are important. The environmental exposure of the individual alters the epigenetic profile through changes in the pattern of DNA methylation, histone modification, or altered action of microRNAs, indicating that in a personalized toxicological approach based on individual variability, both genetic and epigenetic variation should be considered. The intriguing field of toxicoepigenomics and toxicoepigenetics should help translate science into practical personalized health promotion." @default.
- W788121028 created "2016-06-24" @default.
- W788121028 creator A5048668400 @default.
- W788121028 creator A5061826190 @default.
- W788121028 date "2015-01-01" @default.
- W788121028 modified "2023-09-23" @default.
- W788121028 title "Epigenetics of Personalized Toxicology" @default.
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