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• W78813265 abstract "The systematic replacement of nucleotides in DNA fragments isolated by recombinant DNA technology can be achieved by a variety of chemical and enzymatic manipulations. Application of these procedures to DNA that encodes the amino acid sequence of a protein makes it possible to obtain specifically mutated protein when the encoding DNA is expressed in living cells. This variant of genetic engineering — protein engineering by site-directed mutagenesis — is having a major impact on protein structure—function analysis and in the production of proteins with changed or novel properties." @default.
• W78813265 created "2016-06-24" @default.
• W78813265 creator A5088568013 @default.
• W78813265 date "1990-01-01" @default.
• W78813265 modified "2023-09-25" @default.
• W78813265 title "SITE-DIRECTED MUTAGENESIS AND PROTEIN ENGINEERING" @default.
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• W78813265 doi "https://doi.org/10.1016/b978-1-85166-512-9.50006-6" @default.
• W78813265 hasPublicationYear "1990" @default.
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