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- W78819793 abstract "This dissertation describes chemical investigations involving 11 Argentinean plant species and a sample of Chilean propolis. In total, 18 known and four novel compounds were isolated and identified. The compounds were tested in various antimicrobial assays. Three novel triterpenes, 3,4-jeco-olean-12-en-3,28-dioic acid (4), 3a-hydroxyolean-l 1en-28,13 p-olide (5), and 3a-hydroxyolean-ll:13(l8)-dien-28-oic acid (6) were isolated from the aerial parts of the Argentinean shrub, Junellia tridens (Lag.) Mold. (Verbenaceae). Another five compounds, oleanolic acid (1), oleanonic acid (2) and epioleanolic acid (3), all biosynthetically related to the three new oleananes, as well as epibetulinic acid (7) and sitosterol (8), were also isolated. LC-MS data are provided on the occurrence of these triterpenes in six other species of Junellia. We report the minimum inhibitory concentrations (MICs) of compounds 1-8 against Mycobacterium tuberculosis, and conclude that they are responsible for the antitubercular activity originally observed in the crude plant extract. Four other plants showing preliminary antitubercular activity were also investigated. The EtOAc extracts of Acantholippia seriphioides and Adesmia ameghinoi contained oleanolic acid (1) as their main constituent. The organic soluble portions of Chiliotrichium diffidsum and Lathyrus magellanicus contained large amoimts of ursolic acid (12) and sitosterol (8), respectively. Bioassay of the predominant compounds in these plants indicated that triterpenes were responsible for the antitubercular activity observed in the crude extracts. Fractionation of propolis (a product of honey beehives) from Colliguay in Central Chile led to the isolation, identification and bioassay of a novel y-lactone (14), five flavonoids (15-19)," @default.
- W78819793 created "2016-06-24" @default.
- W78819793 creator A5059260112 @default.
- W78819793 date "2000-01-01" @default.
- W78819793 modified "2023-09-23" @default.
- W78819793 title "Chemical investigations of South American plants: Applications to drug discovery, biodiversity conservation and economic development" @default.
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- W78819793 hasPublicationYear "2000" @default.
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