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• W788228116 abstract "Infection of sheep with maedi-visna virus (MVV) causes a multi-organ disease, i.e. encephalitis, pneumonia, mastitis and arthritis. Both the spectrum of organ changes and the character of pathological lesions are similar to that observed in the related lentiviral infection of goats. The tissue tropism of infection with human immunodeficiency virus (HIV) is partly similar and the pathological lesions, especially of the lungs of pediatric patients with AIDS, resemble maedi in sheep. There is a difference in the susceptibility of different breeds of sheep and a variation in the biology of different strains of MVV, reflected in the incidence of different organ manifestations of the infection in various breeds. Thus arthritis has only been observed in American sheep infected with progressive pneumonia virus (PVV) and Icelandic sheep seem to be exceptionally susceptible to encephalitis. A viremia, which develops shortly after infection, apparently plays a major role in the spread of the infection. In American breeds of sheep the main targets of infection are macrophages and they seem to play a key role in development of lesions, whereas in Icelandic sheep a wide variety of cells are permissive for infection with the MW, among them lymphocytes and glial cells. Early lesions have been shown to be immune-mediated, the damaging immune response being directed against virus-induced antigens. A change in the pathogenetic mechanisms may, however, occur with time, as indicated by the appearance of plaques of primary demyelination many years after infection, resembling lesions characteristic of multiple sclerosis." @default.
• W788228116 created "2016-06-24" @default.
• W788228116 creator A5030837956 @default.
• W788228116 date "1990-01-01" @default.
• W788228116 modified "2023-09-26" @default.
• W788228116 title "Maedi - Visna. Pathology and Pathogenesis" @default.
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• W788228116 doi "https://doi.org/10.1007/978-1-4613-1613-8_3" @default.
• W788228116 hasPublicationYear "1990" @default.
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