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- W788257508 abstract "In many human cell types, the class I phosphoinositide 3-kinases play key roles in the control of diverse cellular processes including growth, proliferation, survival and polarity. This is achieved through their activation by many cell surface receptors, leading to the synthesis of the phosphoinositide lipid signal, PIP3, which in turn influences the function of numerous direct PIP3-binding proteins. Here we review PI3K pathway biology and analyse the evolutionary distribution of its components and their functions. The broad phylogenetic distribution of class I PI3Ks in metazoa, amoebozoa and choannoflagellates, implies that these enzymes evolved in single celled organisms and were later co-opted into metazoan intercellular communication. A similar distribution is evident for the AKT and Cytohesin groups of downstream PIP3-binding proteins, with other effectors and pathway components appearing to evolve later. The genomic and functional phylogeny of regulatory systems such as the PI3K pathway provides a framework to improve our understanding of the mechanisms by which key cellular processes are controlled in humans." @default.
- W788257508 created "2016-06-24" @default.
- W788257508 creator A5041829556 @default.
- W788257508 creator A5048051110 @default.
- W788257508 creator A5061697224 @default.
- W788257508 creator A5076039460 @default.
- W788257508 date "2015-09-01" @default.
- W788257508 modified "2023-10-12" @default.
- W788257508 title "Class I PI 3-kinases: Function and evolution" @default.
- W788257508 cites W1963825704 @default.
- W788257508 cites W1966498224 @default.
- W788257508 cites W1966533220 @default.
- W788257508 cites W1966749136 @default.
- W788257508 cites W1977701732 @default.
- W788257508 cites W1984418041 @default.
- W788257508 cites W1984621921 @default.
- W788257508 cites W1987012315 @default.
- W788257508 cites W1991276398 @default.
- W788257508 cites W1995807694 @default.
- W788257508 cites W1998038367 @default.
- W788257508 cites W1999768397 @default.
- W788257508 cites W2005614869 @default.
- W788257508 cites W2006160114 @default.
- W788257508 cites W2006566159 @default.
- W788257508 cites W2008870790 @default.
- W788257508 cites W2009886463 @default.
- W788257508 cites W2010909776 @default.
- W788257508 cites W2012116166 @default.
- W788257508 cites W2012765425 @default.
- W788257508 cites W2017499074 @default.
- W788257508 cites W2017810288 @default.
- W788257508 cites W2019047215 @default.
- W788257508 cites W2021075508 @default.
- W788257508 cites W2021123017 @default.
- W788257508 cites W2025891519 @default.
- W788257508 cites W2026972975 @default.
- W788257508 cites W2027194149 @default.
- W788257508 cites W2030102659 @default.
- W788257508 cites W2036677238 @default.
- W788257508 cites W2038641650 @default.
- W788257508 cites W2042431220 @default.
- W788257508 cites W2043312574 @default.
- W788257508 cites W2047385780 @default.
- W788257508 cites W2047826668 @default.
- W788257508 cites W2048596844 @default.
- W788257508 cites W2048919750 @default.
- W788257508 cites W2054082789 @default.
- W788257508 cites W2054379164 @default.
- W788257508 cites W2057015841 @default.
- W788257508 cites W2057370954 @default.
- W788257508 cites W2057939121 @default.
- W788257508 cites W2061440101 @default.
- W788257508 cites W2061974421 @default.
- W788257508 cites W2062913782 @default.
- W788257508 cites W2063975035 @default.
- W788257508 cites W2068345721 @default.
- W788257508 cites W2069359028 @default.
- W788257508 cites W2070634275 @default.
- W788257508 cites W2077582389 @default.
- W788257508 cites W2082416335 @default.
- W788257508 cites W2083402635 @default.
- W788257508 cites W2086336448 @default.
- W788257508 cites W2087085892 @default.
- W788257508 cites W2087693130 @default.
- W788257508 cites W2087949287 @default.
- W788257508 cites W2095812294 @default.
- W788257508 cites W2096286606 @default.
- W788257508 cites W2099322968 @default.
- W788257508 cites W2101017386 @default.
- W788257508 cites W2106754534 @default.
- W788257508 cites W2112669409 @default.
- W788257508 cites W2115207081 @default.
- W788257508 cites W2119186515 @default.
- W788257508 cites W2119785019 @default.
- W788257508 cites W2120138780 @default.
- W788257508 cites W2124099460 @default.
- W788257508 cites W2128795931 @default.
- W788257508 cites W2133495202 @default.
- W788257508 cites W2133845189 @default.
- W788257508 cites W2134629247 @default.
- W788257508 cites W2140154966 @default.
- W788257508 cites W2146157811 @default.
- W788257508 cites W2146259028 @default.
- W788257508 cites W2146414563 @default.
- W788257508 cites W2152988906 @default.
- W788257508 cites W2154333296 @default.
- W788257508 cites W2154608911 @default.
- W788257508 cites W2159990074 @default.
- W788257508 cites W2161810908 @default.
- W788257508 cites W2162332365 @default.
- W788257508 cites W2163525789 @default.
- W788257508 cites W2163577434 @default.
- W788257508 cites W2163579392 @default.
- W788257508 cites W2164139183 @default.
- W788257508 cites W2165130769 @default.
- W788257508 cites W2166255678 @default.
- W788257508 cites W2169229273 @default.
- W788257508 cites W2171477019 @default.