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- W788267529 abstract "In this study, we investigated whether schizandrin, schizandrin-A, gomisin-A and uridine affect mucin secretion from cultured airway epithelial cells and compared the potential activities of these agents with the inhibitory action on mucin secretion by poly-1-lysine (PLL) and the stimulatory action by adenosine triphosphate (ATP). Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on secretion. The results were as follows: schizandrin-A and uridine increased mucin secretion at the highest concentrations (). We conclude that schizandrin-A and uridine can stimulate mucin secretion via direct effect on airway mucin-secreting cells and suggest that these agents be further investigated for the potential use as mucoregulators during the treatment of chronic airway diseases." @default.
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- W788267529 date "2006-01-01" @default.
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- W788267529 title "Effects of Three Compounds from Schizandrae Fructus and Uridine on Airway Mucin Secretion" @default.
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