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- W78830487 abstract "Abstract Recent studies identified and partially characterized the Th9 lineage, using anti- CD3/CD28 Abs for activation during polarization. Using TCR transgenic mice we showed, however, that Th9 are also generated by activation with the specific Ag, hen egg lysozyme (HEL) (J. Imm., 185:6795, 2010). Here, we compared Th9 lines generated by either HEL, or anti-CD3/CD28 Abs, but similarly polarized by IL-4/TGF-β. Main observations: (i) IL-9 and IL-10 are similarly secreted in the supernatant by HEL or Ab-activated cultures. Intracellular IL-9 is expressed earlier in the Ab-activated cells, but IL-10 is similarly produced by the two subsets. (ii) Both subsets induced ocular inflammation when adoptively transferred into mice expressing HEL in their eyes, but pathogenicity of Ag-stimulated Th9 was restricted to day 3 in culture, whereas Ab-stimulated Th9 induced disease when collected after 3-5 days in culture. (iii) The two Th9 subsets expressed similarly the majority of tested major surface Ags, but differed in expression of CD45RB, CD69, α4β7 and αEβ7. (iv) The two Th9 subsets differed remarkably in their expression of several chemokine and chemokine receptor transcripts, with patterns strikingly similar to those reported for the two Th17 subsets. Thus, different modes of activation of naïve CD4 cells during polarization yield two distinct subpopulations of Th9." @default.
- W78830487 created "2016-06-24" @default.
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- W78830487 date "2011-04-01" @default.
- W78830487 modified "2023-09-23" @default.
- W78830487 title "Two distinct Th9 subpopulations are generated by activating naïve CD4 cells with either antigen/APC, or anti-CD3/CD28 antibodies (152.12)" @default.
- W78830487 doi "https://doi.org/10.4049/jimmunol.186.supp.152.12" @default.
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