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• W788386412 abstract "Summary A number of immunomodulatory effects have been attributed to the medicinal plants Calendula officinalis and Echinacea angustifolia ; however, little is known about whether treatment with these plants can enhance antigen-specific immunity. Two groups of birds, a vaccinated group (n=25) and a saline injected control (n=35), were subjected to the blast transformation test. The birds were primed with two water-in-oil emulsified vaccines, against Newcastle disease, infectious bursitis, infectious bronchitis and viral arteritis (Quadractin) as well as against Pasteurella multocida , serotypes 1,3 and 5 (Cholerin triple), were administered subcutaneously, in a dose of 0,5 ml/bird, as antigen priming. The blast transformation test was done in vitro, using five alcoholic vegetal extractions ( Calendula officinalis, Echinaceea angustifolia , E. purpureea, Urtica dioica and Aloe vera ) and monitoring their effect in comparison with alcohol and/or no treatment, at each of the samplings, three weeks apart. The results indicated that, in the dosage applied in vitro and at the moments selected for the testing of blast transformation capacities, the alcoholic extractions of Calendula, Echinaceea angustifolia , E. purpureea, Urtica dioica and Aloe vera could not restore the level of cell mediated reactivity to its ante-priming values on short term. Still, antigen primed, vegetal extraction treated cells gave a better in vitro response. This effect was due to the combined treatment, not to the vaccination alone. A number of immunomodulatory effects have been attributed to the medicinal plants Calendula officinalis and Echinacea angustifolia ; however, little is known about whether treatment with these plants can enhance antigen-specific immunity. Investigations conducted on rats over a period of 6 weeks showed that the Echinacea treatment significantly augmented of the primary and secondary IgG response to the antigen. These results suggested that medicinal plants like Echinacea may enhance immune function by increasing antigen- specific immunoglobulin production (El-Gengaihi et all.,1998 ). In this context the stimulation of the oxidative burst as well as the modulation on monokine secretion were reviewed (Attele et all., 1999). Meanwhile, from the water or alcaline-water extracts of Calendula officinalis L., polysaccharide fractions with molecular weights in the range of 25000 to 500000 and higher have been isolated, which, according to the granulocytes- and carbon clearance tests, showed si gnificant immune stimulating activities. The isolated compounds belong to the group of water soluble, acidic branched-chain heteroglycans (Mashaly et all., 2000 )." @default.
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• W788386412 date "2007-01-01" @default.
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• W788386412 title "Specific cell-mediated immune changes induced by the in vitro administration of various vegetal extractions in antigen primed hens." @default.
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