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- W78859128 abstract "Using fluorescein-labelled glycosaminoglycans (F-GAG) an extensive study of their pharmacokinetics and of pharmacokinetics of their lipoprotein lipase-inducing activity was carried out in fed and fasted rats. A two-compartment model was used to describe F-GAG's pharmacokinetics. The parameters of drug disposition were strongly dose-dependent. The dose-response curves for parameters were powers with negative exponent indicating considerable saturation of the F-GAG elimination process. There was also dose dependence for T1/2, Co, AUC and Cl, and the decrease in lipoprotein lipase activity in plasma was strongly dose-dependent. The lipoprotein lipase kinetic parameters also appeared to be dose-dependent." @default.
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- W78859128 date "1982-01-01" @default.
- W78859128 modified "2023-09-27" @default.
- W78859128 title "Pharmacokinetics of fluorescein-labelled glycosaminoglycans and of their lipoprotein lipase-inducing activity in the rat." @default.
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