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- W788968116 abstract "2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is formed with other chlorinated dibenzo-p-dioxins when alkali metal salts of chlorinated phenols are heated to high temperatures (Langer et al. 1973), so it is a potential contaminant of a wide range of industrial products. In fact at least part of the toxicity observed with many technical grade chlorinated aromatic chemicals, such as 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) (Kimmig and Schulz 1957; Poland and Smith 1971) and pentachlorophenol (Baader and Bauer 1951; Goldstein et al. 1977), both in humans occupationally exposed and in laboratory animals, has been attributed to contamination with chlorinated dibenzo-p-dioxins. TCDD is one of the most toxic small molecules known, causing delayed death of guinea pigs at a dose as low as 1 µg/kg (Schwetz et al. 1973). It provokes pathological changes in the liver, thymus, skin, and immune system (Jones and Butler 1974; Gupta et al. 1973; Schulz 1957; Vos et al. 1973); moreover its chemical stability and persistance in the environment (Kearney et al. 1973) pose additional hazards." @default.
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- W788968116 date "1981-01-01" @default.
- W788968116 modified "2023-09-27" @default.
- W788968116 title "Early Changes in the Urinary Excretion of Porphyrins by Female Rats in the Course of Chronic TCDD Treatment" @default.
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- W788968116 doi "https://doi.org/10.1007/978-3-642-68195-0_43" @default.
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