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• W788972034 endingPage "e1004973" @default.
• W788972034 startingPage "e1004973" @default.
• W788972034 abstract "HIV-1 vaccines designed to date have failed to elicit neutralizing antibodies (Nabs) that are capable of protecting against globally diverse HIV-1 subtypes. One relevant setting to study the development of a strong, cross-reactive Nab response is HIV-1 superinfection (SI), defined as sequential infections from different source partners. SI has previously been shown to lead to a broader and more potent Nab response when compared to single infection, but it is unclear whether SI also impacts epitope specificity and if the epitopes targeted after SI differ from those targeted after single infection. Here the post-SI Nab responses were examined from 21 Kenyan women collectively exposed to subtypes A, C, and D and superinfected after a median time of ~1.07 years following initial infection. Plasma samples chosen for analysis were collected at a median time point ~2.72 years post-SI. Because previous studies of singly infected populations with broad and potent Nab responses have shown that the majority of their neutralizing activity can be mapped to 4 main epitopes on the HIV-1 Envelope, we focused on these targets, which include the CD4-binding site, a V1/V2 glycan, the N332 supersite in V3, and the membrane proximal external region of gp41. Using standard epitope mapping techniques that were applied to the previous cohorts, the present study demonstrates that SI did not induce a dominant Nab response to any one of these epitopes in the 21 women. Computational sera delineation analyses also suggested that 20 of the 21 superinfected women's Nab responses could not be ascribed a single specificity with high confidence. These data are consistent with a model in which SI with diverse subtypes promotes the development of a broad polyclonal Nab response, and thus would provide support for vaccine designs using multivalent HIV immunogens to elicit a diverse repertoire of Nabs." @default.
• W788972034 created "2016-06-24" @default.
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• W788972034 date "2015-07-09" @default.
• W788972034 modified "2023-10-13" @default.
• W788972034 title "The Broad Neutralizing Antibody Responses after HIV-1 Superinfection Are Not Dominated by Antibodies Directed to Epitopes Common in Single Infection" @default.
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• W788972034 cites W1967115540 @default.
• W788972034 cites W1974273518 @default.
• W788972034 cites W1979058462 @default.
• W788972034 cites W1986243552 @default.
• W788972034 cites W1987510779 @default.
• W788972034 cites W1989174077 @default.
• W788972034 cites W1992529182 @default.
• W788972034 cites W1996720451 @default.
• W788972034 cites W1998683102 @default.
• W788972034 cites W1999483871 @default.
• W788972034 cites W2000886957 @default.
• W788972034 cites W2005816484 @default.
• W788972034 cites W2009151161 @default.
• W788972034 cites W2010959676 @default.
• W788972034 cites W2011611846 @default.
• W788972034 cites W2012362118 @default.
• W788972034 cites W2014764918 @default.
• W788972034 cites W2023273943 @default.
• W788972034 cites W2024427410 @default.
• W788972034 cites W2029135056 @default.
• W788972034 cites W2031604171 @default.
• W788972034 cites W2032682068 @default.
• W788972034 cites W2035541600 @default.
• W788972034 cites W2036549279 @default.
• W788972034 cites W2037320559 @default.
• W788972034 cites W2040949532 @default.
• W788972034 cites W2042613186 @default.
• W788972034 cites W2046563994 @default.
• W788972034 cites W2048787904 @default.
• W788972034 cites W2053127269 @default.
• W788972034 cites W2057119574 @default.
• W788972034 cites W2061962974 @default.
• W788972034 cites W2064815276 @default.
• W788972034 cites W2068757386 @default.
• W788972034 cites W2070086938 @default.
• W788972034 cites W2077977162 @default.
• W788972034 cites W2083726777 @default.
• W788972034 cites W2084310667 @default.
• W788972034 cites W2086641359 @default.
• W788972034 cites W2089766500 @default.
• W788972034 cites W2095497026 @default.
• W788972034 cites W2102548388 @default.
• W788972034 cites W2102949556 @default.
• W788972034 cites W2108096886 @default.
• W788972034 cites W2109229894 @default.
• W788972034 cites W2111763401 @default.
• W788972034 cites W2112310185 @default.
• W788972034 cites W2112329925 @default.
• W788972034 cites W2113236498 @default.
• W788972034 cites W2115951500 @default.
• W788972034 cites W2118274231 @default.
• W788972034 cites W2122387808 @default.
• W788972034 cites W2127249709 @default.
• W788972034 cites W2128461524 @default.
• W788972034 cites W2131332541 @default.
• W788972034 cites W2135151522 @default.
• W788972034 cites W2135847964 @default.
• W788972034 cites W2137939749 @default.
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• W788972034 cites W2138922145 @default.
• W788972034 cites W2143585030 @default.
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• W788972034 doi "https://doi.org/10.1371/journal.ppat.1004973" @default.
• W788972034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4497680" @default.
• W788972034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26158467" @default.
• W788972034 hasPublicationYear "2015" @default.
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