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- W78903477 abstract "This chapter discusses the tricarboxylate (TCA) cycle. The role of the TCA cycle is not confined to the degradation of acetyl-CoA. The cycle is a central metabolic pathway involved in both catabolic and anabolic processes. The chapter also describes entry of pyruvate into the mitochondrion and the oxidative decarboxylation of pyruvate. The acetyl groups of acetyl-CoA enter the TCA cycle by condensation with oxaloacetate to form citrate. The reaction, catalysed by citrate synthase, occurs in two stages: the formation of a citryl-CoA enzyme-bound intermediate that is hydrolysed to yield citrate and coenzyme A. Citrate is converted into another TCA, isocitrate, because the position of the hydroxyl group prevents its direct oxidation. The process of filling up the pool of cycle intermediates is called, from appropriate Greek roots, anaplerosis. Anaplerotic reactions may also be employed in anabolic functions. The TCA cycle is regulated in accordance with its function as a supplier of reduced coenzymes for oxidative phosphorylation. The main purpose of the glyoxylate cycle that is located in glyoxysomes of plants is the synthesis of succinate from which carbohydrate may be produced." @default.
- W78903477 created "2016-06-24" @default.
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- W78903477 date "1989-01-01" @default.
- W78903477 modified "2023-10-16" @default.
- W78903477 title "The tricarboxylate cycle" @default.
- W78903477 doi "https://doi.org/10.1016/b978-0-7236-1151-6.50018-2" @default.
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