Matches in SemOpenAlex for { <https://semopenalex.org/work/W789050937> ?p ?o ?g. }
- W789050937 endingPage "386" @default.
- W789050937 startingPage "377" @default.
- W789050937 abstract "During clot formation, platelets are subjected to various different signals and cues as they dynamically interact with extracellular matrix proteins such as von Willebrand factor (vWF), fibrin(ogen) and collagen. While the downstream signaling of platelet-ligand interactions is well-characterized, biophysical cues, such as hydrodynamic forces and mechanical stiffness of the underlying substrate, also mediate these interactions and affect the binding kinetics of platelets to these proteins. Recent studies have observed that, similar to nucleated cells, platelets mechanosense their microenvironment and exhibit dynamic physiologic responses to biophysical cues. This review discusses how platelet mechanosensing is affected by the hydrodynamic forces that dictate vWF-platelet interactions and fibrin polymerization and network formation. The similarities and differences in mechanosensing between platelets and nucleated cells and integrin-mediated platelet mechanosensing on both fibrin(ogen) and collagen are then reviewed. Further studies investigating how platelets interact with the mechanical microenvironment will improve our overall understanding of the hemostatic process." @default.
- W789050937 created "2016-06-24" @default.
- W789050937 creator A5033332146 @default.
- W789050937 creator A5033742668 @default.
- W789050937 creator A5049999061 @default.
- W789050937 creator A5065031384 @default.
- W789050937 creator A5066552119 @default.
- W789050937 date "2015-11-01" @default.
- W789050937 modified "2023-10-13" @default.
- W789050937 title "Platelets and physics: How platelets “feel” and respond to their mechanical microenvironment" @default.
- W789050937 cites W119409406 @default.
- W789050937 cites W1482392342 @default.
- W789050937 cites W1507708600 @default.
- W789050937 cites W1543980776 @default.
- W789050937 cites W1554303836 @default.
- W789050937 cites W1560618466 @default.
- W789050937 cites W1576773659 @default.
- W789050937 cites W1578980777 @default.
- W789050937 cites W1579617174 @default.
- W789050937 cites W1824468361 @default.
- W789050937 cites W1835746053 @default.
- W789050937 cites W1895802579 @default.
- W789050937 cites W1931265512 @default.
- W789050937 cites W1965112825 @default.
- W789050937 cites W1966073555 @default.
- W789050937 cites W1966558481 @default.
- W789050937 cites W1972832497 @default.
- W789050937 cites W1973897127 @default.
- W789050937 cites W1977564287 @default.
- W789050937 cites W1977602054 @default.
- W789050937 cites W1977751952 @default.
- W789050937 cites W1981248837 @default.
- W789050937 cites W1981421731 @default.
- W789050937 cites W1982536372 @default.
- W789050937 cites W1984353324 @default.
- W789050937 cites W1985318253 @default.
- W789050937 cites W1985975155 @default.
- W789050937 cites W1986162817 @default.
- W789050937 cites W1987139499 @default.
- W789050937 cites W1987384052 @default.
- W789050937 cites W1987789195 @default.
- W789050937 cites W1990439612 @default.
- W789050937 cites W1993079150 @default.
- W789050937 cites W1997614271 @default.
- W789050937 cites W1998539678 @default.
- W789050937 cites W1998596396 @default.
- W789050937 cites W2000465700 @default.
- W789050937 cites W2002062380 @default.
- W789050937 cites W2004614757 @default.
- W789050937 cites W2005464779 @default.
- W789050937 cites W2005532545 @default.
- W789050937 cites W2005937826 @default.
- W789050937 cites W2007097623 @default.
- W789050937 cites W2007206486 @default.
- W789050937 cites W2008423937 @default.
- W789050937 cites W2011739619 @default.
- W789050937 cites W2011830638 @default.
- W789050937 cites W2012230802 @default.
- W789050937 cites W2022851623 @default.
- W789050937 cites W2025713519 @default.
- W789050937 cites W2026298111 @default.
- W789050937 cites W2029271892 @default.
- W789050937 cites W2035972050 @default.
- W789050937 cites W2036265613 @default.
- W789050937 cites W2038164789 @default.
- W789050937 cites W2038933685 @default.
- W789050937 cites W2039881470 @default.
- W789050937 cites W2040030547 @default.
- W789050937 cites W2042208046 @default.
- W789050937 cites W2043555344 @default.
- W789050937 cites W2046060386 @default.
- W789050937 cites W2047204651 @default.
- W789050937 cites W2048410146 @default.
- W789050937 cites W2049718632 @default.
- W789050937 cites W2050393694 @default.
- W789050937 cites W2050701385 @default.
- W789050937 cites W2052405788 @default.
- W789050937 cites W2053305824 @default.
- W789050937 cites W2054267707 @default.
- W789050937 cites W2054635074 @default.
- W789050937 cites W2055588429 @default.
- W789050937 cites W2056563854 @default.
- W789050937 cites W2059289129 @default.
- W789050937 cites W2061229454 @default.
- W789050937 cites W2061801043 @default.
- W789050937 cites W2071831995 @default.
- W789050937 cites W2073150096 @default.
- W789050937 cites W2075013504 @default.
- W789050937 cites W2076086205 @default.
- W789050937 cites W2078132464 @default.
- W789050937 cites W2080484884 @default.
- W789050937 cites W2081350035 @default.
- W789050937 cites W2085435652 @default.
- W789050937 cites W2087069387 @default.
- W789050937 cites W2090659127 @default.
- W789050937 cites W2091401363 @default.
- W789050937 cites W2092447350 @default.
- W789050937 cites W2095299313 @default.