FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W78979483> ?p ?o ?g. }

• W78979483 endingPage "1060" @default.
• W78979483 startingPage "1042" @default.
• W78979483 abstract "In order to better understand the role of histamine H4 (H4R) receptor in breast cancer, we studied the receptor expression pattern, associated signal transduction pathway and biological responses, in breast cancer cell lines with different malignant characteristics. A different pattern of protein expression was observed in MDA-MB-231 compared to MCF-7 cells determined by western blot, exhibiting the presence of a diverse range of molecular weight species of the H4R. H4R agonist reduced cyclic adenosine monophosphate (cAMP) formation induced by forskolin only in MCF-7 cells. In MDA-MB-231 cells, H4R agonists significantly decreased cell roliferation, augmented the Annexin-V and TdT-mediated UTP-biotin Nick End labelling (TUNEL) positive cells and produced a 2.5-fold increase in cell senescence. In MCF-7 cells, H4R agonists inhibited proliferation by 50%, increasing the exponential doubling time. This effect was associated to an augment in Annexin-V and TUNEL positive cells, and a 2-fold increase in cell senescence. We conclude that H4R is functionally expressed in human breast cancer cell lines, exhibiting a key role in histamine-mediated biological processes such as cell proliferation, senescence and apoptosis." @default.
• W78979483 created "2016-06-24" @default.
• W78979483 creator A5026462253 @default.
• W78979483 creator A5029926740 @default.
• W78979483 creator A5034425650 @default.
• W78979483 creator A5046211177 @default.
• W78979483 creator A5057324519 @default.
• W78979483 creator A5066459639 @default.
• W78979483 creator A5081613920 @default.
• W78979483 creator A5083391834 @default.
• W78979483 date "2011-01-01" @default.
• W78979483 modified "2023-10-16" @default.
• W78979483 title "Role of histamine H4 receptor in breast cancer cell proliferation" @default.
• W78979483 doi "https://doi.org/10.2741/e310" @default.
• W78979483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21622113" @default.
• W78979483 hasPublicationYear "2011" @default.
• W78979483 type Work @default.
• W78979483 sameAs 78979483 @default.
• W78979483 citedByCount "17" @default.
• W78979483 countsByYear W789794832012 @default.
• W78979483 countsByYear W789794832013 @default.
• W78979483 countsByYear W789794832014 @default.
• W78979483 countsByYear W789794832015 @default.
• W78979483 countsByYear W789794832016 @default.
• W78979483 countsByYear W789794832017 @default.
• W78979483 countsByYear W789794832019 @default.
• W78979483 countsByYear W789794832020 @default.
• W78979483 countsByYear W789794832022 @default.
• W78979483 countsByYear W789794832023 @default.
• W78979483 crossrefType "journal-article" @default.
• W78979483 hasAuthorship W78979483A5026462253 @default.
• W78979483 hasAuthorship W78979483A5029926740 @default.
• W78979483 hasAuthorship W78979483A5034425650 @default.
• W78979483 hasAuthorship W78979483A5046211177 @default.
• W78979483 hasAuthorship W78979483A5057324519 @default.
• W78979483 hasAuthorship W78979483A5066459639 @default.
• W78979483 hasAuthorship W78979483A5081613920 @default.
• W78979483 hasAuthorship W78979483A5083391834 @default.
• W78979483 hasConcept C1122143 @default.
• W78979483 hasConcept C121608353 @default.
• W78979483 hasConcept C126322002 @default.
• W78979483 hasConcept C134018914 @default.
• W78979483 hasConcept C153911025 @default.
• W78979483 hasConcept C170493617 @default.
• W78979483 hasConcept C185592680 @default.
• W78979483 hasConcept C190283241 @default.
• W78979483 hasConcept C2776885963 @default.
• W78979483 hasConcept C2779276759 @default.
• W78979483 hasConcept C30862142 @default.
• W78979483 hasConcept C34400551 @default.
• W78979483 hasConcept C502942594 @default.
• W78979483 hasConcept C55493867 @default.
• W78979483 hasConcept C62112901 @default.
• W78979483 hasConcept C62478195 @default.
• W78979483 hasConcept C71924100 @default.
• W78979483 hasConcept C86803240 @default.
• W78979483 hasConcept C88634738 @default.
• W78979483 hasConcept C95444343 @default.
• W78979483 hasConcept C96232424 @default.
• W78979483 hasConceptScore W78979483C1122143 @default.
• W78979483 hasConceptScore W78979483C121608353 @default.
• W78979483 hasConceptScore W78979483C126322002 @default.
• W78979483 hasConceptScore W78979483C134018914 @default.
• W78979483 hasConceptScore W78979483C153911025 @default.
• W78979483 hasConceptScore W78979483C170493617 @default.
• W78979483 hasConceptScore W78979483C185592680 @default.
• W78979483 hasConceptScore W78979483C190283241 @default.
• W78979483 hasConceptScore W78979483C2776885963 @default.
• W78979483 hasConceptScore W78979483C2779276759 @default.
• W78979483 hasConceptScore W78979483C30862142 @default.
• W78979483 hasConceptScore W78979483C34400551 @default.
• W78979483 hasConceptScore W78979483C502942594 @default.
• W78979483 hasConceptScore W78979483C55493867 @default.
• W78979483 hasConceptScore W78979483C62112901 @default.
• W78979483 hasConceptScore W78979483C62478195 @default.
• W78979483 hasConceptScore W78979483C71924100 @default.
• W78979483 hasConceptScore W78979483C86803240 @default.
• W78979483 hasConceptScore W78979483C88634738 @default.
• W78979483 hasConceptScore W78979483C95444343 @default.
• W78979483 hasConceptScore W78979483C96232424 @default.
• W78979483 hasIssue "3" @default.
• W78979483 hasLocation W789794831 @default.
• W78979483 hasLocation W789794832 @default.
• W78979483 hasOpenAccess W78979483 @default.
• W78979483 hasPrimaryLocation W789794831 @default.
• W78979483 hasRelatedWork W1983461608 @default.
• W78979483 hasRelatedWork W1989170543 @default.
• W78979483 hasRelatedWork W2005432427 @default.
• W78979483 hasRelatedWork W2030476651 @default.
• W78979483 hasRelatedWork W2033731685 @default.
• W78979483 hasRelatedWork W2043572826 @default.
• W78979483 hasRelatedWork W2143924810 @default.
• W78979483 hasRelatedWork W2339826654 @default.
• W78979483 hasRelatedWork W2522836974 @default.
• W78979483 hasRelatedWork W78979483 @default.
• W78979483 hasVolume "E3" @default.
• W78979483 isParatext "false" @default.
• W78979483 isRetracted "false" @default.

• next