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- W79059464 abstract "Abstract The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be identified. It was initially cloned based on its connection with a relatively rare pediatric cancer of the same name. Analysis of the gene and protein in both normal physiology and cancer pathogenesis over the past three decades has generated a wealth of information about its function. It is ubiquitously expressed and possesses many functions that impinge on cell proliferation and fate decisions, cell viability, and genome integrity. Furthermore, elimination of its function is widespread in cancer, irrespective of disease site, indicating that overcoming retinoblastoma gene function is critical to cancer initiation and progression." @default.
- W79059464 created "2016-06-24" @default.
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- W79059464 date "2015-01-01" @default.
- W79059464 modified "2023-09-26" @default.
- W79059464 title "Retinoblastoma Tumor Suppressor Gene" @default.
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- W79059464 doi "https://doi.org/10.1016/b978-0-12-801238-3.04443-3" @default.
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