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- W79061520 abstract "Correspondence: MJ Zibaeenezhad, Cardiovascular Research Center, Shahid Faghihi Hospital, Zand Blvd., Shiraz, Iran. Tel/Fax: +98-711-2343529, Email: zi�aeem2�sums.ac.ir Background: Unfractioned heparin (UFH) is the standard antithrom�otic agent in elective percutaneous coronary intervention (PCI), �ut has its own limitations. Several studies have suggested intravenous enoxaparin as a safe and effective alternative �ut most of them are uncontrolled. Our main goal was to evaluate the safety of enoxaparin over UFH in PCI patients undergoing coronary stenting �y drug eluting stents (DES). Methods: We randomly assigned 195 patients undergoing PCI using DES to receive either 0.75 mg enoxaparin per kilogram of �ody weight or 10000 IU unfractioned heparin. The primary end point was the incidence of major or minor �leeding . The secondary end point was the incidence of acute coronary events (ST-elevation myocardial infarction, non ST-elevation myocardial infarction,and unstable angina) in the first 24 hours after PCI. Results: The rate of major and minor bleedings was similar in the first 24 hours after procedure between enoxaparin group and UFH group ( P value>0.05). The incidence of acute coronary events and mortality was also similar �etween two arms. Conclusion: In DES �ased PCI , a single intravenous �olus of 0.75 mg of enoxaparin per kilogram is associated with similar rate of �leeding as compaired with UFH. Also the rates of ischemic events are not different for enoxaparin and UFH however larger trials are needed for definit conclusion." @default.
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- W79061520 date "2007-09-30" @default.
- W79061520 modified "2023-09-23" @default.
- W79061520 title "Safety of enoxaparin versus unfractioned heparin in patients undergoing percutaneous coronary intervention using drug eluting stents: A pilot study" @default.
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