Matches in SemOpenAlex for { <https://semopenalex.org/work/W790709994> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W790709994 endingPage "160" @default.
- W790709994 startingPage "155" @default.
- W790709994 abstract "Human immunodeficiency virus type 1 (HIV-1) protease is essential for the replication of the virus and it is therefore an attractive target for antiviral drugs of HIV-1. Several dipeptide isosteres containing 2-isoxazoline or -hydroxy ketomethylene have been synthesized and their inhibitory effects on the HIV-1 protease examined. The enzymatically active HIV-1 protease was purified to homogeniety from E. coli transformed with a recombinant plasmid (pMAL-pro) containing the entire gene encoding the protease. The purified protease had the substrate specificity with Km value of 9.8M when an undecapeptide His-Lys-Ala-Arg-Val-Leu-(p-nitro)Phe-Glu-Ala-Nle-Ser-amide was used as a substrate, and the products from the substrate after specific cleavage by HIV-1 protease were analyzed by HPLC. The synthetic compounds containing dipeptide isosteres showed specific inhibitory effects while a dipeptide isostere containing an isoxazoline ring inhibited the HIV-1 protease competitively with Ki value of 500 M. Even if the inhibition effects of HIV-1 protease were not very high, these novel dipeptide isosteres can be used as key structural moieties for developing specific inhibitors of HIV-1 protease." @default.
- W790709994 created "2016-06-24" @default.
- W790709994 creator A5029928770 @default.
- W790709994 creator A5037554967 @default.
- W790709994 creator A5040920159 @default.
- W790709994 creator A5085660248 @default.
- W790709994 date "1994-01-01" @default.
- W790709994 modified "2023-09-26" @default.
- W790709994 title "Inhibition of HIV-1 Pretense by Novel Dipeptide Isosteres Containing 2-Isoxazoline or $alpha$-Hydroxy Ketomethylene" @default.
- W790709994 hasPublicationYear "1994" @default.
- W790709994 type Work @default.
- W790709994 sameAs 790709994 @default.
- W790709994 citedByCount "0" @default.
- W790709994 crossrefType "journal-article" @default.
- W790709994 hasAuthorship W790709994A5029928770 @default.
- W790709994 hasAuthorship W790709994A5037554967 @default.
- W790709994 hasAuthorship W790709994A5040920159 @default.
- W790709994 hasAuthorship W790709994A5085660248 @default.
- W790709994 hasConcept C142462285 @default.
- W790709994 hasConcept C159047783 @default.
- W790709994 hasConcept C180000673 @default.
- W790709994 hasConcept C181199279 @default.
- W790709994 hasConcept C185592680 @default.
- W790709994 hasConcept C2776714187 @default.
- W790709994 hasConcept C2777583353 @default.
- W790709994 hasConcept C2779138802 @default.
- W790709994 hasConcept C2779281246 @default.
- W790709994 hasConcept C2781143361 @default.
- W790709994 hasConcept C2993143319 @default.
- W790709994 hasConcept C3013748606 @default.
- W790709994 hasConcept C55493867 @default.
- W790709994 hasConcept C71240020 @default.
- W790709994 hasConcept C86803240 @default.
- W790709994 hasConceptScore W790709994C142462285 @default.
- W790709994 hasConceptScore W790709994C159047783 @default.
- W790709994 hasConceptScore W790709994C180000673 @default.
- W790709994 hasConceptScore W790709994C181199279 @default.
- W790709994 hasConceptScore W790709994C185592680 @default.
- W790709994 hasConceptScore W790709994C2776714187 @default.
- W790709994 hasConceptScore W790709994C2777583353 @default.
- W790709994 hasConceptScore W790709994C2779138802 @default.
- W790709994 hasConceptScore W790709994C2779281246 @default.
- W790709994 hasConceptScore W790709994C2781143361 @default.
- W790709994 hasConceptScore W790709994C2993143319 @default.
- W790709994 hasConceptScore W790709994C3013748606 @default.
- W790709994 hasConceptScore W790709994C55493867 @default.
- W790709994 hasConceptScore W790709994C71240020 @default.
- W790709994 hasConceptScore W790709994C86803240 @default.
- W790709994 hasIssue "2" @default.
- W790709994 hasLocation W7907099941 @default.
- W790709994 hasOpenAccess W790709994 @default.
- W790709994 hasPrimaryLocation W7907099941 @default.
- W790709994 hasRelatedWork W1480478945 @default.
- W790709994 hasRelatedWork W1978107630 @default.
- W790709994 hasRelatedWork W2013520316 @default.
- W790709994 hasRelatedWork W2015866424 @default.
- W790709994 hasRelatedWork W2021881285 @default.
- W790709994 hasRelatedWork W2036375691 @default.
- W790709994 hasRelatedWork W2044621720 @default.
- W790709994 hasRelatedWork W2045774983 @default.
- W790709994 hasRelatedWork W2077068955 @default.
- W790709994 hasRelatedWork W2093032026 @default.
- W790709994 hasRelatedWork W2114742412 @default.
- W790709994 hasRelatedWork W2134418875 @default.
- W790709994 hasRelatedWork W2136227671 @default.
- W790709994 hasRelatedWork W2506150632 @default.
- W790709994 hasRelatedWork W2949967281 @default.
- W790709994 hasRelatedWork W2950987658 @default.
- W790709994 hasRelatedWork W2952331817 @default.
- W790709994 hasRelatedWork W2839492105 @default.
- W790709994 hasRelatedWork W3145898407 @default.
- W790709994 hasRelatedWork W975905831 @default.
- W790709994 hasVolume "2" @default.
- W790709994 isParatext "false" @default.
- W790709994 isRetracted "false" @default.
- W790709994 magId "790709994" @default.
- W790709994 workType "article" @default.