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- W791436902 abstract "In the 1890s, Robert Koch observed that a primary infection of guinea pigs with Mycobacterium tuberculosis in the skin produced a nonhealing lesion and that reinoculation of the animals after several weeks produced only a firm, red nodule that necrosed and finally healed. These observations first suggested the existence of immunity to tuberculosis infection. While T-cell-derived lymphokines and the activated macrophage represent a necessary condition for protection, it is certainly not the whole story even in the mouse. A large proportion of human peripheral blood γδ T cells, even from PPD-negative donors, will proliferate in response to mycobacteria. Recent experiments involving M. tuberculosis infection of transgenic mice are providing new and interesting information on the role of some lymphokines and cytokines. In many chronic infections or inflammatory diseases, there is a permanent or transient switch from a Th1 pattern of response to Th2. Such a switch appears to occur, for example, in schistosomiasis and syphilis patients. The tissue-damaging responses are evoked by tuberculin, which is a very crude culture supernatant from old autolysing bacterial cultures precipitated by trichloroacetic acid or ammonium sulfate. Such supernatants contain fragments of essentially all the antigens of M. tuberculosis. The known capacity of mycobacterium containing adjuvants (Freund's complete adjuvant) to facilitate experimental induction of autoimmunity and evidence that mycobacterial disease can be accompanied by a sterile arthropathy have reawakened speculation that some autoimmune syndromes may be cryptic infections or may be triggered by past encounters with mycobacterium-like organisms." @default.
- W791436902 created "2016-06-24" @default.
- W791436902 creator A5015758456 @default.
- W791436902 creator A5090498605 @default.
- W791436902 date "2014-04-08" @default.
- W791436902 modified "2023-10-16" @default.
- W791436902 title "Mechanisms of Pathogenesis in Tuberculosis" @default.
- W791436902 cites W1514549604 @default.
- W791436902 cites W1581305040 @default.
- W791436902 cites W1585904443 @default.
- W791436902 cites W1600829515 @default.
- W791436902 cites W1928278408 @default.
- W791436902 cites W1929705279 @default.
- W791436902 cites W1930233965 @default.
- W791436902 cites W1941717575 @default.
- W791436902 cites W1955931243 @default.
- W791436902 cites W1965077361 @default.
- W791436902 cites W1966333025 @default.
- W791436902 cites W1967463166 @default.
- W791436902 cites W1967945767 @default.
- W791436902 cites W1971028997 @default.
- W791436902 cites W1980941499 @default.
- W791436902 cites W1985459937 @default.
- W791436902 cites W1987175676 @default.
- W791436902 cites W1990197546 @default.
- W791436902 cites W1996470996 @default.
- W791436902 cites W1996644394 @default.
- W791436902 cites W1997021659 @default.
- W791436902 cites W1997340636 @default.
- W791436902 cites W1997833625 @default.
- W791436902 cites W2000498962 @default.
- W791436902 cites W2007606955 @default.
- W791436902 cites W2021236886 @default.
- W791436902 cites W2022706923 @default.
- W791436902 cites W2022721580 @default.
- W791436902 cites W2030438607 @default.
- W791436902 cites W2031680867 @default.
- W791436902 cites W2032996592 @default.
- W791436902 cites W2036260827 @default.
- W791436902 cites W2038907536 @default.
- W791436902 cites W2046219096 @default.
- W791436902 cites W2047460038 @default.
- W791436902 cites W2048597976 @default.
- W791436902 cites W2054930447 @default.
- W791436902 cites W2054941139 @default.
- W791436902 cites W2057123987 @default.
- W791436902 cites W2057409071 @default.
- W791436902 cites W2057516079 @default.
- W791436902 cites W2063669781 @default.
- W791436902 cites W2065317013 @default.
- W791436902 cites W2066046731 @default.
- W791436902 cites W2066698332 @default.
- W791436902 cites W2067219370 @default.
- W791436902 cites W2073132923 @default.
- W791436902 cites W2074190213 @default.
- W791436902 cites W2074873520 @default.
- W791436902 cites W2075942059 @default.
- W791436902 cites W2076171364 @default.
- W791436902 cites W2078433846 @default.
- W791436902 cites W2083037372 @default.
- W791436902 cites W2083325443 @default.
- W791436902 cites W2083642617 @default.
- W791436902 cites W2084833522 @default.
- W791436902 cites W2089262366 @default.
- W791436902 cites W2089475252 @default.
- W791436902 cites W2091660386 @default.
- W791436902 cites W2091999380 @default.
- W791436902 cites W2092032854 @default.
- W791436902 cites W2092034926 @default.
- W791436902 cites W2094543727 @default.
- W791436902 cites W2100939719 @default.
- W791436902 cites W2109484445 @default.
- W791436902 cites W2114628825 @default.
- W791436902 cites W2122573572 @default.
- W791436902 cites W2123036801 @default.
- W791436902 cites W2123051270 @default.
- W791436902 cites W2127368077 @default.
- W791436902 cites W2129480311 @default.
- W791436902 cites W2130046741 @default.
- W791436902 cites W2132954949 @default.
- W791436902 cites W2138705853 @default.
- W791436902 cites W2151612737 @default.
- W791436902 cites W2154341106 @default.
- W791436902 cites W2156669028 @default.
- W791436902 cites W2158035277 @default.
- W791436902 cites W2162559503 @default.
- W791436902 cites W2163957811 @default.
- W791436902 cites W2168145528 @default.
- W791436902 cites W2170450192 @default.
- W791436902 cites W2171414034 @default.
- W791436902 cites W2172009888 @default.
- W791436902 cites W2501302160 @default.
- W791436902 cites W3024998677 @default.
- W791436902 cites W4233529952 @default.
- W791436902 doi "https://doi.org/10.1128/9781555818357.ch28" @default.
- W791436902 hasPublicationYear "2014" @default.
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