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- W79192035 abstract "Toxicity of two antimonial pentavalents were evaluated in 111 patients with cutaneousleishmaniasis. Forty seven patients received meglumine antimoniate (Group I) and 64 patients,sodium stibogluconate BP 88® (Group II), 20mg SbV/kg/day for 20 days. Evaluation ofaminotransferases, alkaline phosphatase, amilase, creatinine, urea, urine analysis andelectrocardiogram were performed at baseline, on the tenth and twentieth day of treatment. Greaterfrequency of aminotransferase abnormal levels were observed on the tenth and twentieth days ingroup II (p < 0,001) and a greater proportion of amilase abnormal levels at the tenth day in thesame group (p < 0,001). There was a greater variation of aminotransferases, alkaline phosphataseand amilase in the first ten days of treatment in group II (p < 0,01). On the twentieth day there wasa greater variation of aminotransferase levels in group II (p = 0,02 and p = 0,03, respectively).Forty three percent of group I and 54% of group II showed electrocardiographic abnormalities(p = 0,30)." @default.
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- W79192035 date "2000-01-01" @default.
- W79192035 modified "2023-10-15" @default.
- W79192035 title "Estudo comparativo entre estibogluconato de sódio BP 88© e antimoniato de meglumina no tratamento da leishmaniose cutânea: Toxidade bioquímica e cardíaca / Comparative study between sodium stibogluconate BP 88© and meglumine antimoniate in cutaneous leishmaniasis treatment: Biochemical and cardiac toxicity" @default.
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