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• W79215721 abstract "Parkinson’s disease is a neurodegenerative disorder involving the progressive degeneration of dopamine neurons arising in the substantia nigra compacta area and terminating in the striatum. Dopamine replacement therapy by administration of l-dopa has been developed based on a specific loss of pigmented substantia nigra compacta (A9 nigral) neurons and striatal dopamine. However, dopamine replacement therapy has failed to stop the progression of the disease. The major objective is to develop a better therapeutic approach to the treatment and prevention of the disease. In the past few years much has been discovered about the chemical pathology of Parkinson’ s disease. This new information gives hope not only for finding the cause of the disease, but also for developing new preventive drugs that may either halt the progressive degeneration of the A9 nigral neurons or, perhaps, provide means to rescue these dopamine neurons. The current hypothesis concerning the pathogenesis of Parkinson’s disease holds that there is an ongoing selective oxidative stress that cannot be thoroughly investigated using brain tissues obtained during autopsy. Much of what we have learned about oxidative neurodegeneration have come from studies with 6-hydroxydopamine (1,2) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)—a neurotoxin that produces animal model for investigating oxidative stress and Parkinsonian syndrome (3,4,5)." @default.
• W79215721 created "2016-06-24" @default.
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• W79215721 date "2000-01-01" @default.
• W79215721 modified "2023-09-24" @default.
• W79215721 title "Neuroprotective Strategies in Parkinson’s Disease and Huntington’s Chorea" @default.
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• W79215721 doi "https://doi.org/10.1007/978-1-59259-692-8_20" @default.
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