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- W792186539 abstract "Adenosine 5'-triphosphate (ATP) has been shown to be an important extracellular signalingmolecule that mediates various physiological activities via the P2 (P2X and P2Y) receptors.However, information on the expression patterns of the P2 receptors during mammalianembryogenesis is limited. We therefore examined the expression patterns of different P2receptor subtypes in rat embryos. In the hindbrain neural tube, the P2X3 receptor wastransiently expressed at embryonic day E11 in the cranial motor neurons and the outgrowingaxons. ATP significantly inhibited neurite outgrowth from neural tube explants. P2X3receptors were also prominently expressed in sensory ganglia at this early stage and werecoexpressed with P2X2 receptors in E16.5 embryos. Other P2X receptor subtypes wereobserved in different brain regions such as subventricular zones, the site of postnatalneurogenesis. In addition, the P2Y receptor expression was detected in the somites andsubsequently in the developing skeletal muscle but was downregulated as developmentproceeded. While the P2Y1 receptor was no longer expressed in the adult skeletal muscle, theexpression of P2Y2 receptor was present, although restricted in the satellite cells and the P2Y4receptor showed reduced expression in adult skeletal muscle. Likewise, the expression of theP2Y receptors was initially expressed throughout the myocardium (E12) but was graduallyrestricted to the trabeculated myocardium (E14-18). Studies on Ca2+ influx showed that particular P2 receptor subtypes of P2X2, P2X4, P2Yi, P2Y2, P2Y4 and P2Y6 receptorsresponded to nucleotides in E14 cardiomyocytes. P2X7 receptor expression was detected indeveloping pancreatic islet cells and later coexpressed with glucagon in a-cells. In addition,transient expression of the P2X7 receptor in insulin-expressing cells was observed in theembryonic, but not in adult, islet cells. Together, the results indicated that widespread anddynamic expression of P2 receptors was found in the three-germ layer-derived embryonictissues, particularly in some transient embryonic structures during development, whichsuggested they may be important in embryonic organogenesis." @default.
- W792186539 created "2016-06-24" @default.
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- W792186539 date "2004-01-01" @default.
- W792186539 modified "2023-09-24" @default.
- W792186539 title "Purinergic signaling during rat embryonic development" @default.
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- W792186539 hasPublicationYear "2004" @default.
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