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• W792651160 abstract "Leslie and Gardner reported in 1931 that Bordetella pertussis could grow in any of four different phases (phases I to IV). These phases were distinguished by colony morphology, hemolysis, and antigenic profile. Subsequent reports differed on the exact number and nature of the phases of B. pertussis. By 1983 the biochemical characterization of B. pertussis had defined several virulence-associated proteins. Pertussis toxin, perceived to be one of the most important, had been purified, characterized biochemically, and shown to be an ADP-ribosylating toxin with host GTP-binding proteins as cellular targets. Filamentous hemagglutinin (FHA), believed to be important in the specific adherence that B. pertussis demonstrates to the ciliated epithelium, had also been purified. It was also known that B. pertussis made fimbriae and a novel toxin, the extracytoplasmic adenylate cyclase toxin. The original DNA sequence predicted the presence of three fevg-encoded polypeptides, two of which shared significant sequence similarity with a large family of bacterial regulatory proteins commonly called two-component systems. The fha and bvg operons are distinguished from other bvg-regulated genes by their ability to respond to the presence of BvgA and BvgS in Escherichia coli. The frl gene products function as transcriptional activators that control the expression of several loci, including the structural gene for an alternative sigma factor, sigma F. Sigma F then activates late genes which include the flagellin locus. frlAB is the first-characterized example of an auxiliary regulatory locus within the bvg regulon." @default.
• W792651160 created "2016-06-24" @default.
• W792651160 creator A5005953351 @default.
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• W792651160 date "2014-04-30" @default.
• W792651160 modified "2023-09-23" @default.
• W792651160 title "Coordinate Regulation of Virulence in Bordetella pertussis Mediated by the vir (bvg) Locus" @default.
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• W792651160 doi "https://doi.org/10.1128/9781555818340.ch27" @default.
• W792651160 hasPublicationYear "2014" @default.
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