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- W79295965 abstract "Smokers constitute a majority of patients with cancer and hence, are frequently subjected to vaccination. Vaccines, designed to enhance host immunity against infectious agents and neoplastic cells, depend on functional dendritic cells (DCs), the body's key immune cells that are pivotal in the initiation immune responses. Our recent studies indicate that the presence of nicotine in the microenvironment severely affects the properties of DCs and impairs their ability to induce the development of effective immune responses. These observations raised some doubts on the ability of cancer vaccines to generate sufficient immune responses in smokers in order to mediate tumor regression or prevent tumor occurrence. Thus, in this study, we investigated whether the adverse effects of nicotine on DC system decrease the effectiveness of cancer vaccines in tumor-bearing mice exposed to nicotine. We found that the vaccine effectively controls the tumor growth in control mice. However, the same vaccine provides little tumor regression in nicotine-exposed mice as evidenced by a larger tumor mass. We also found that compared to control mice, lymphoid cells isolated from nicotine-exposed mice produce up to 50% less IFN-γ after re-exposure to tumor antigen and exhibit markedly reduced CTL killing activity against inoculated tumor cells. Collectively, our data suggests that vaccines provide only partial protection in nicotine-exposed individuals. Philip Morris USA Inc., and Philip Morris International." @default.
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- W79295965 date "2008-03-01" @default.
- W79295965 modified "2023-09-25" @default.
- W79295965 title "Nicotine impairs cancer vaccines" @default.
- W79295965 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1077.25" @default.
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