Matches in SemOpenAlex for { <https://semopenalex.org/work/W793004944> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W793004944 endingPage "72" @default.
- W793004944 startingPage "63" @default.
- W793004944 abstract "Previous work from our laboratory has demonstrated that T lymphocyte-derived cytokine, interferon-gamma (IFN-γ) may play a role in human luteal regression by inhibiting luteal progesterone production. Prostaglandin F2a has been known as an important luteolytic factor in a wide range of mammalian species. It was of interest to investigate the effects of IFN-γ on prostaglandin synthesis and their possible interaction with the inhibition on human luteal steroidogenesis. Human luteal cells were cultured for four days in the presence or absence of IFN-γ. Simultaneously, the productions of progesterone, prostaglandin F2a ( PGF2a ), prostaglandin E2 ( PGE2 ), and 6-ketoprostaglandin F1a(PGF1a) were evaluated. Concomitant with the inhibition of progesterone production induced by IFN-γ, a biphasic pattern of response of. prostaglandin synthesis was observed, i.e. a slight decrease of PGF2a and PGF1a after a 48 h exposure to IFN-γ while an increase of PGE2 after 96 h. In a separate experiment, a luteotropic action of PGE2 and PGF2a on human luteal cells from different stages was observed during 48 and 96 h periods of culture. In addition, while indomethacin (INDO) treatment markedly blocked the prostaglandin synthesis, the basal as well as hCG stimulated progesterone production was still inhibited by IFN-γ as usual. These results suggested that prostaglandins appeared to be not responsible for the observed inhibition of progesterone production since the inhibitory effect was not influenced by concurrent treatment with INDO which suppressed prostaglandin synthesis," @default.
- W793004944 created "2016-06-24" @default.
- W793004944 creator A5001410362 @default.
- W793004944 creator A5002562771 @default.
- W793004944 creator A5054552842 @default.
- W793004944 creator A5079320268 @default.
- W793004944 creator A5079527409 @default.
- W793004944 date "1996-01-01" @default.
- W793004944 modified "2023-09-23" @default.
- W793004944 title "Effects and Interactions of Prostaglandins and Interferon-γ on Steroidogenesis of Human Luteal Cells" @default.
- W793004944 hasPublicationYear "1996" @default.
- W793004944 type Work @default.
- W793004944 sameAs 793004944 @default.
- W793004944 citedByCount "0" @default.
- W793004944 crossrefType "journal-article" @default.
- W793004944 hasAuthorship W793004944A5001410362 @default.
- W793004944 hasAuthorship W793004944A5002562771 @default.
- W793004944 hasAuthorship W793004944A5054552842 @default.
- W793004944 hasAuthorship W793004944A5079320268 @default.
- W793004944 hasAuthorship W793004944A5079527409 @default.
- W793004944 hasConcept C126322002 @default.
- W793004944 hasConcept C134018914 @default.
- W793004944 hasConcept C143228043 @default.
- W793004944 hasConcept C185592680 @default.
- W793004944 hasConcept C187785154 @default.
- W793004944 hasConcept C2776608385 @default.
- W793004944 hasConcept C2777198256 @default.
- W793004944 hasConcept C2777956040 @default.
- W793004944 hasConcept C2779837120 @default.
- W793004944 hasConcept C2780664492 @default.
- W793004944 hasConcept C71315377 @default.
- W793004944 hasConcept C71924100 @default.
- W793004944 hasConcept C86803240 @default.
- W793004944 hasConceptScore W793004944C126322002 @default.
- W793004944 hasConceptScore W793004944C134018914 @default.
- W793004944 hasConceptScore W793004944C143228043 @default.
- W793004944 hasConceptScore W793004944C185592680 @default.
- W793004944 hasConceptScore W793004944C187785154 @default.
- W793004944 hasConceptScore W793004944C2776608385 @default.
- W793004944 hasConceptScore W793004944C2777198256 @default.
- W793004944 hasConceptScore W793004944C2777956040 @default.
- W793004944 hasConceptScore W793004944C2779837120 @default.
- W793004944 hasConceptScore W793004944C2780664492 @default.
- W793004944 hasConceptScore W793004944C71315377 @default.
- W793004944 hasConceptScore W793004944C71924100 @default.
- W793004944 hasConceptScore W793004944C86803240 @default.
- W793004944 hasIssue "2" @default.
- W793004944 hasLocation W7930049441 @default.
- W793004944 hasOpenAccess W793004944 @default.
- W793004944 hasPrimaryLocation W7930049441 @default.
- W793004944 hasRelatedWork W1971148565 @default.
- W793004944 hasRelatedWork W1988952930 @default.
- W793004944 hasRelatedWork W1994284786 @default.
- W793004944 hasRelatedWork W2053865302 @default.
- W793004944 hasRelatedWork W2055753544 @default.
- W793004944 hasRelatedWork W2066460764 @default.
- W793004944 hasRelatedWork W2076547002 @default.
- W793004944 hasRelatedWork W2092866101 @default.
- W793004944 hasRelatedWork W2109864949 @default.
- W793004944 hasRelatedWork W2129893034 @default.
- W793004944 hasRelatedWork W2159869967 @default.
- W793004944 hasRelatedWork W2316036154 @default.
- W793004944 hasRelatedWork W2403761630 @default.
- W793004944 hasRelatedWork W2404925129 @default.
- W793004944 hasRelatedWork W2418549527 @default.
- W793004944 hasRelatedWork W2472511590 @default.
- W793004944 hasRelatedWork W2591942867 @default.
- W793004944 hasRelatedWork W2015963776 @default.
- W793004944 hasRelatedWork W2186750652 @default.
- W793004944 hasRelatedWork W2340299331 @default.
- W793004944 hasVolume "7" @default.
- W793004944 isParatext "false" @default.
- W793004944 isRetracted "false" @default.
- W793004944 magId "793004944" @default.
- W793004944 workType "article" @default.