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• W793344894 abstract "This thesis is focussed on developing new methods and outcomes to assess respiratoryfunction that require little or no volitional effort on behalf of the participants beingtested. Specifically to attempt to detach the behaviour of the patient from the accuracyof the test of respiratory function, resulting in techniques that are simpler and easier toadminister and undertake for both assessor and participant. It aims to develop methodsthat reduce the involvement of the participant during assessment of respiratoryfunction. The human body’s way of controlling respiration has evolved into asophisticated system that optimises breathing pattern to maintain the most efficienthomeostatic action of the respiratory system. Eliciting and assessing this automaticresponse is the key to removing the action of participation from respiratory functiontesting. The focus must therefore be on developing non-invasive, sub-maximaltechniques that allow participants to enter into a steady state of respiration and howthis can be assessed.Two techniques were investigated; Respiratory Endurance (as the inspiratory work ofbreathing) and Tidal Breathing Flow Profile, and these were successfully applied in99 adult participants (68 healthy controls and 31 COPD patients) and 75 children (48clinical group and 27 healthy controls) who completed 467 respiratory endurancetrials whilst seated and exercising, and 249 relaxed tidal breathing trials.The difficulties with lung function assessment are well established and have beendescribed in this thesis. Much recent emphasis has been put on developing existingdevices and protocols rather than developing new techniques and approaching thesedifficulties from alternative viewpoints. This thesis has described the development of innovative techniques to assess the function of the respiratory systems that aim toovercome the issues associated with maximal testing. It was shown that thesetechniques are easy to undertake for a range of participants, simple to analyse and areable to reliably differentiate between health and disease, suggesting that they couldbecome a useful adjunct to existing methods of respiratory assessment." @default.
• W793344894 created "2016-06-24" @default.
• W793344894 creator A5005571197 @default.
• W793344894 date "2010-01-01" @default.
• W793344894 modified "2023-09-27" @default.
• W793344894 title "Work of breathing in exercise and disease" @default.
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