FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W793430949> ?p ?o ?g. }

• W793430949 endingPage "191" @default.
• W793430949 startingPage "179" @default.
• W793430949 abstract "Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on continuing hyaluronan synthesis, and disrupt upon digestion of hyaluronan by hyaluronidase. However, complete understanding of their nature is still missing. This work shows that the protrusions on rat peritoneal surface are ultrastructurally indistinguishable from those induced by GFP-HAS3 in MCF-7 cells. Analysis of the actin-associated proteins villin, ezrin, espin, fascin, and Myo10 indicated that the HAS3-induced protrusions share most cytoskeletal features with filopodia, but they do not require adherence to the substratum like traditional filopodia. GFP-HAS3 overexpression was found to markedly enhance filamentous actin in the protrusions and their cortical basis. Analysis of the protrusion dynamics after enzymatic digestion of hyaluronan revealed that while GFP-HAS3 escape from the protrusions and the protrusion collapse takes place immediately, the complete retraction of the protrusions occurs more slowly. This finding also suggests that hyaluronan chain maintains HAS3 in the plasma membrane. The results of this work suggest that protrusions similar to those of HAS3 overexpressing cells in vitro exist also in cells with active hyaluronan synthesis in vivo. These protrusions are similar to common filopodia but are independent of substratum attachment due to the extracellular scaffolding by the hyaluronan coat that accounts for the growth and maintenance of these structures, previously associated to invasion, adhesion and multidrug resistance." @default.
• W793430949 created "2016-06-24" @default.
• W793430949 creator A5030385925 @default.
• W793430949 creator A5040942714 @default.
• W793430949 creator A5079366524 @default.
• W793430949 creator A5081325199 @default.
• W793430949 creator A5082176270 @default.
• W793430949 creator A5088605616 @default.
• W793430949 date "2015-10-01" @default.
• W793430949 modified "2023-09-25" @default.
• W793430949 title "Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia" @default.
• W793430949 cites W164399989 @default.
• W793430949 cites W1972905290 @default.
• W793430949 cites W1976773752 @default.
• W793430949 cites W1981589473 @default.
• W793430949 cites W1989108940 @default.
• W793430949 cites W1994665652 @default.
• W793430949 cites W1997180743 @default.
• W793430949 cites W1998289520 @default.
• W793430949 cites W2002441880 @default.
• W793430949 cites W2005703350 @default.
• W793430949 cites W2006292913 @default.
• W793430949 cites W2014983646 @default.
• W793430949 cites W2017990098 @default.
• W793430949 cites W2019627505 @default.
• W793430949 cites W2022199933 @default.
• W793430949 cites W2027480013 @default.
• W793430949 cites W2031133866 @default.
• W793430949 cites W2033052708 @default.
• W793430949 cites W2045274781 @default.
• W793430949 cites W2045973674 @default.
• W793430949 cites W2046593161 @default.
• W793430949 cites W2049343601 @default.
• W793430949 cites W2059274538 @default.
• W793430949 cites W2061072525 @default.
• W793430949 cites W2068923263 @default.
• W793430949 cites W2073326952 @default.
• W793430949 cites W2074238963 @default.
• W793430949 cites W2087317113 @default.
• W793430949 cites W2093024719 @default.
• W793430949 cites W2099300318 @default.
• W793430949 cites W2099356631 @default.
• W793430949 cites W2105503408 @default.
• W793430949 cites W2108372612 @default.
• W793430949 cites W2129959101 @default.
• W793430949 cites W2130480967 @default.
• W793430949 cites W2134371395 @default.
• W793430949 cites W2134437854 @default.
• W793430949 cites W2141313486 @default.
• W793430949 cites W2142649252 @default.
• W793430949 cites W2150174045 @default.
• W793430949 cites W2150751366 @default.
• W793430949 cites W2157314109 @default.
• W793430949 cites W2161367729 @default.
• W793430949 cites W2168014973 @default.
• W793430949 cites W2277083338 @default.
• W793430949 cites W266429416 @default.
• W793430949 cites W1804134220 @default.
• W793430949 doi "https://doi.org/10.1016/j.yexcr.2015.06.016" @default.
• W793430949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26162854" @default.
• W793430949 hasPublicationYear "2015" @default.
• W793430949 type Work @default.
• W793430949 sameAs 793430949 @default.
• W793430949 citedByCount "24" @default.
• W793430949 countsByYear W7934309492015 @default.
• W793430949 countsByYear W7934309492016 @default.
• W793430949 countsByYear W7934309492017 @default.
• W793430949 countsByYear W7934309492018 @default.
• W793430949 countsByYear W7934309492019 @default.
• W793430949 countsByYear W7934309492020 @default.
• W793430949 countsByYear W7934309492021 @default.
• W793430949 countsByYear W7934309492022 @default.
• W793430949 countsByYear W7934309492023 @default.
• W793430949 crossrefType "journal-article" @default.
• W793430949 hasAuthorship W793430949A5030385925 @default.
• W793430949 hasAuthorship W793430949A5040942714 @default.
• W793430949 hasAuthorship W793430949A5079366524 @default.
• W793430949 hasAuthorship W793430949A5081325199 @default.
• W793430949 hasAuthorship W793430949A5082176270 @default.
• W793430949 hasAuthorship W793430949A5088605616 @default.
• W793430949 hasConcept C109185818 @default.
• W793430949 hasConcept C125705527 @default.
• W793430949 hasConcept C142669718 @default.
• W793430949 hasConcept C1491633281 @default.
• W793430949 hasConcept C199528912 @default.
• W793430949 hasConcept C2778934503 @default.
• W793430949 hasConcept C55493867 @default.
• W793430949 hasConcept C86803240 @default.
• W793430949 hasConcept C90301020 @default.
• W793430949 hasConcept C95444343 @default.
• W793430949 hasConceptScore W793430949C109185818 @default.
• W793430949 hasConceptScore W793430949C125705527 @default.
• W793430949 hasConceptScore W793430949C142669718 @default.
• W793430949 hasConceptScore W793430949C1491633281 @default.
• W793430949 hasConceptScore W793430949C199528912 @default.
• W793430949 hasConceptScore W793430949C2778934503 @default.
• W793430949 hasConceptScore W793430949C55493867 @default.
• W793430949 hasConceptScore W793430949C86803240 @default.

• next