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- W793439947 abstract "Acute graft-versus-host disease (GVHD) is a systemic manifestation of activation of normal allodisparate transplanted lymphoid cells to recipient epithelial target organs. In clinical bone marrow transplantation (BMT) between HLA identical siblings, acute GVHD occurs in up to 50% of cases,1 many times during the early posttransplant period. It has recently been shown that FK 506 is superior to cyclosporine (CyA) for the prevention of lethal acute GVHD after allogeneic bone marrow transplantation in the rat.2 It is known that FK 506 compared to CyA in vitro has a higher potency with regard to its effects on the early events of T-cell activation, particularly if FK 506 is present at or before the time of antigenic stimulation. We have examined whether a single treatment of the allogeneic donor, either alone, in combination with continuous recipient prophylactic therapy, or with discontinuous recipient therapy, could significantly prolong the GVHD-free interval and subsequent overall survival after fully allogeneic bone marrow transplantation in our previously described animal model. 2" @default.
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- W793439947 date "1991-12-01" @default.
- W793439947 modified "2023-09-23" @default.
- W793439947 title "Prolonged prevention of acute graft-versus-host disease after allogeneic bone marrow transplantation by donor pretreatment using FK 506." @default.
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