Matches in SemOpenAlex for { <https://semopenalex.org/work/W79347247> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W79347247 endingPage "150" @default.
- W79347247 startingPage "141" @default.
- W79347247 abstract "Objective: To report an 18-month follow-up on creatine and minocycline futility study, the Neuroprotective Exploratory Trials in Parkinson Disease, Futility Study 1 (NET-PD FS-1). Background: The NET-PD FS-1 futility study on creatine and minocycline found neither agent futile in slowing down the progression of disability in Parkinson disease (PD) at 12 months using the prespecified futility threshold. An additional 6 months of follow-up aimed to assess safety and potential interactions of the study interventions with antiparkinsonian therapy. Methods: Additional 6 months of follow-up in randomized, blinded phase II trial of creatine (dosage, 10 g/d) and minocycline (dosage, 200 mg/d) in subjects with early PD. Results: By 18 months, symptomatic treatment of PD symptoms was required in 61% of creatine, 62% of minocycline, and 60% of placebo-treated subjects. Study treatment was prematurely discontinued in 9%, 23%, and 6% of subjects in the creatine, minocycline, and placebo arms, respectively. Creatine and minocycline did not seem to adversely influence the response to symptomatic therapy nor increase adverse events. Conclusions: Data from this small, 18-month phase II trial of creatine and minocycline do not demonstrate safety concerns that would preclude a large, phase III efficacy trial, although the decreased tolerability of minocycline is a concern." @default.
- W79347247 created "2016-06-24" @default.
- W79347247 creator A5087128383 @default.
- W79347247 date "2008-05-01" @default.
- W79347247 modified "2023-10-05" @default.
- W79347247 title "A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease" @default.
- W79347247 cites W1572230556 @default.
- W79347247 cites W1954166865 @default.
- W79347247 cites W1972991508 @default.
- W79347247 cites W1974800756 @default.
- W79347247 cites W2036609824 @default.
- W79347247 cites W2062781235 @default.
- W79347247 cites W2073839177 @default.
- W79347247 cites W2081374761 @default.
- W79347247 cites W2091323080 @default.
- W79347247 cites W2092838550 @default.
- W79347247 cites W2103738800 @default.
- W79347247 cites W2114862320 @default.
- W79347247 cites W2122094983 @default.
- W79347247 cites W2136570995 @default.
- W79347247 cites W2145189131 @default.
- W79347247 cites W2145337544 @default.
- W79347247 cites W2148726772 @default.
- W79347247 cites W2339005630 @default.
- W79347247 cites W2358364508 @default.
- W79347247 doi "https://doi.org/10.1097/wnf.0b013e3181342f32" @default.
- W79347247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4372145" @default.
- W79347247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18520981" @default.
- W79347247 hasPublicationYear "2008" @default.
- W79347247 type Work @default.
- W79347247 sameAs 79347247 @default.
- W79347247 citedByCount "149" @default.
- W79347247 countsByYear W793472472012 @default.
- W79347247 countsByYear W793472472013 @default.
- W79347247 countsByYear W793472472014 @default.
- W79347247 countsByYear W793472472015 @default.
- W79347247 countsByYear W793472472016 @default.
- W79347247 countsByYear W793472472017 @default.
- W79347247 countsByYear W793472472018 @default.
- W79347247 countsByYear W793472472019 @default.
- W79347247 countsByYear W793472472020 @default.
- W79347247 countsByYear W793472472021 @default.
- W79347247 countsByYear W793472472022 @default.
- W79347247 countsByYear W793472472023 @default.
- W79347247 crossrefType "journal-article" @default.
- W79347247 hasAuthorship W79347247A5087128383 @default.
- W79347247 hasBestOaLocation W793472472 @default.
- W79347247 hasConcept C126322002 @default.
- W79347247 hasConcept C142724271 @default.
- W79347247 hasConcept C168563851 @default.
- W79347247 hasConcept C197934379 @default.
- W79347247 hasConcept C204787440 @default.
- W79347247 hasConcept C27081682 @default.
- W79347247 hasConcept C2778275353 @default.
- W79347247 hasConcept C2778375690 @default.
- W79347247 hasConcept C2779896295 @default.
- W79347247 hasConcept C501593827 @default.
- W79347247 hasConcept C535046627 @default.
- W79347247 hasConcept C71924100 @default.
- W79347247 hasConcept C86803240 @default.
- W79347247 hasConcept C89423630 @default.
- W79347247 hasConceptScore W79347247C126322002 @default.
- W79347247 hasConceptScore W79347247C142724271 @default.
- W79347247 hasConceptScore W79347247C168563851 @default.
- W79347247 hasConceptScore W79347247C197934379 @default.
- W79347247 hasConceptScore W79347247C204787440 @default.
- W79347247 hasConceptScore W79347247C27081682 @default.
- W79347247 hasConceptScore W79347247C2778275353 @default.
- W79347247 hasConceptScore W79347247C2778375690 @default.
- W79347247 hasConceptScore W79347247C2779896295 @default.
- W79347247 hasConceptScore W79347247C501593827 @default.
- W79347247 hasConceptScore W79347247C535046627 @default.
- W79347247 hasConceptScore W79347247C71924100 @default.
- W79347247 hasConceptScore W79347247C86803240 @default.
- W79347247 hasConceptScore W79347247C89423630 @default.
- W79347247 hasIssue "3" @default.
- W79347247 hasLocation W793472471 @default.
- W79347247 hasLocation W793472472 @default.
- W79347247 hasLocation W793472473 @default.
- W79347247 hasOpenAccess W79347247 @default.
- W79347247 hasPrimaryLocation W793472471 @default.
- W79347247 hasRelatedWork W1966047811 @default.
- W79347247 hasRelatedWork W2003042623 @default.
- W79347247 hasRelatedWork W202460821 @default.
- W79347247 hasRelatedWork W2030348591 @default.
- W79347247 hasRelatedWork W2036609824 @default.
- W79347247 hasRelatedWork W2068849886 @default.
- W79347247 hasRelatedWork W2109235243 @default.
- W79347247 hasRelatedWork W2147606462 @default.
- W79347247 hasRelatedWork W3023502736 @default.
- W79347247 hasRelatedWork W4308071420 @default.
- W79347247 hasVolume "31" @default.
- W79347247 isParatext "false" @default.
- W79347247 isRetracted "false" @default.
- W79347247 magId "79347247" @default.
- W79347247 workType "article" @default.