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- W79400416 abstract "Objective: An antidepressants tolerability, generally captured as the frequency and severity of adverse events (AEs), is often as important as its efficacy in determining treatment success. This study used a composite outcome remission of major depressive disorder (MDD) without AEs to compare the benefit/risk profiles of escitalopram versus the norepinephrine reuptake inhibitors (SNRIs) duloxetine and venlafaxine extended release (XR). Methods: Pooled data from three randomized, doubleblind, multicenter trials were analyzed, in which patients with MDD were treated for 8 weeks with either escitalopram (n=462) or an SNRI (n=467). Main outcome measures: The composite outcome was defined as remission (Montgomery-Asberg Depression Rating Scale [MADRS] score ≤10) and concurrent absence of an AE. The proportions of remitted patients free of (1) any AEs, (2) moderate-to-severe AEs, and (3) study drugrelated AEs were compared between treatment groups at each study visit and longitudinally across study visits common to all trials during the first 8 weeks of treatment. Results: At endpoint (week 8), escitalopram-treated patients were more likely than SNRI-treated patients to experience remission free of any AEs (28.4 vs. 21.6%; p=0.0179) and remission free of study drug-related AEs (45.2 vs. 36.8%; p=0.0092). Compared to SNRItreated patients, escitalopram-treated patients had 38% greater odds of remission free of any AEs, 28% greater odds of remission free of moderateto-severe AEs, and 34% greater odds of remission free of study drugrelated AEs (all p" @default.
- W79400416 created "2016-06-24" @default.
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- W79400416 date "2011-01-01" @default.
- W79400416 modified "2023-09-26" @default.
- W79400416 title "Ремиссия большого депрессивного расстройства без нежелательных явлений терапии: сравнение эсциталопрама с ингибиторами обратного захвата серотонина и норадреналина" @default.
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