Matches in SemOpenAlex for { <https://semopenalex.org/work/W79403648> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W79403648 endingPage "80" @default.
- W79403648 startingPage "375" @default.
- W79403648 abstract "Air embolization has been shown to produce a reversible permeability-type of pulmonary oedema. The present study investigated the haemodynamic, gasometric and haematological changes associated with air infusion in the spontaneously breathing dog (weight 31 +/- 5 kg). Air was infused at a rate of 10 ml X min-1 for 60 min (10 dogs) or 180 min (5 dogs). During the air infusion, a dramatic increase in pulmonary artery pressure was associated with only a moderate increase in right atrial pressure and limited decreases in arterial pressure and in cardiac output. A marked decrease in end-tidal PCO2 reflected the increase in dead space. These changes were stable during air infusion, but rapidly reversed after the end of infusion. However, hypoxaemia, defined by a decreased PaO2/PAO2 ratio, deteriorated with time and was only partially reversible. At histological examination, interstitial pulmonary oedema was present around the pulmonary arterioles. Air infusion was associated with rapid decreases in circulating leukocytes and platelets and complement activation. Since leukotriene release might be associated with leukocyte activation in this model, seven additional dogs were pretreated by inhalation of 10 mg of the leukotriene inhibitor U-60,257. The increase in pulmonary vascular resistance and in pulmonary shunt were moderately reduced and the drop in circulating leukocytes and platelets was strikingly abolished in the treated animals. Air infusion in the spontaneously breathing dog represents a model of very stable and reversible pulmonary hypertension. It can reproduce important pathophysiological features implicated in the development of pulmonary oedema.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W79403648 created "2016-06-24" @default.
- W79403648 creator A5002589661 @default.
- W79403648 creator A5006354484 @default.
- W79403648 creator A5010279300 @default.
- W79403648 creator A5027005599 @default.
- W79403648 creator A5040484264 @default.
- W79403648 creator A5055785476 @default.
- W79403648 creator A5067060548 @default.
- W79403648 creator A5071183263 @default.
- W79403648 creator A5084556180 @default.
- W79403648 date "1986-07-01" @default.
- W79403648 modified "2023-09-23" @default.
- W79403648 title "Haemodynamic, gasometric and haematological effects of air infusion in dogs: leukotriene inhibition with U-60,257." @default.
- W79403648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3094608" @default.
- W79403648 hasPublicationYear "1986" @default.
- W79403648 type Work @default.
- W79403648 sameAs 79403648 @default.
- W79403648 citedByCount "1" @default.
- W79403648 crossrefType "journal-article" @default.
- W79403648 hasAuthorship W79403648A5002589661 @default.
- W79403648 hasAuthorship W79403648A5006354484 @default.
- W79403648 hasAuthorship W79403648A5010279300 @default.
- W79403648 hasAuthorship W79403648A5027005599 @default.
- W79403648 hasAuthorship W79403648A5040484264 @default.
- W79403648 hasAuthorship W79403648A5055785476 @default.
- W79403648 hasAuthorship W79403648A5067060548 @default.
- W79403648 hasAuthorship W79403648A5071183263 @default.
- W79403648 hasAuthorship W79403648A5084556180 @default.
- W79403648 hasConcept C126322002 @default.
- W79403648 hasConcept C139940330 @default.
- W79403648 hasConcept C164705383 @default.
- W79403648 hasConcept C178853913 @default.
- W79403648 hasConcept C2776042228 @default.
- W79403648 hasConcept C2776452501 @default.
- W79403648 hasConcept C2777140959 @default.
- W79403648 hasConcept C2777714996 @default.
- W79403648 hasConcept C2780940725 @default.
- W79403648 hasConcept C42219234 @default.
- W79403648 hasConcept C58245268 @default.
- W79403648 hasConcept C71924100 @default.
- W79403648 hasConceptScore W79403648C126322002 @default.
- W79403648 hasConceptScore W79403648C139940330 @default.
- W79403648 hasConceptScore W79403648C164705383 @default.
- W79403648 hasConceptScore W79403648C178853913 @default.
- W79403648 hasConceptScore W79403648C2776042228 @default.
- W79403648 hasConceptScore W79403648C2776452501 @default.
- W79403648 hasConceptScore W79403648C2777140959 @default.
- W79403648 hasConceptScore W79403648C2777714996 @default.
- W79403648 hasConceptScore W79403648C2780940725 @default.
- W79403648 hasConceptScore W79403648C42219234 @default.
- W79403648 hasConceptScore W79403648C58245268 @default.
- W79403648 hasConceptScore W79403648C71924100 @default.
- W79403648 hasIssue "4" @default.
- W79403648 hasLocation W794036481 @default.
- W79403648 hasOpenAccess W79403648 @default.
- W79403648 hasPrimaryLocation W794036481 @default.
- W79403648 hasRelatedWork W1981010395 @default.
- W79403648 hasRelatedWork W2010738716 @default.
- W79403648 hasRelatedWork W2021468243 @default.
- W79403648 hasRelatedWork W2046852523 @default.
- W79403648 hasRelatedWork W2134878907 @default.
- W79403648 hasRelatedWork W2374927284 @default.
- W79403648 hasRelatedWork W2409095210 @default.
- W79403648 hasRelatedWork W2418231705 @default.
- W79403648 hasRelatedWork W2418566360 @default.
- W79403648 hasRelatedWork W2475327391 @default.
- W79403648 hasVolume "22" @default.
- W79403648 isParatext "false" @default.
- W79403648 isRetracted "false" @default.
- W79403648 magId "79403648" @default.
- W79403648 workType "article" @default.