FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W794091443> ?p ?o ?g. }

• W794091443 endingPage "691" @default.
• W794091443 startingPage "685" @default.
• W794091443 abstract "Matrix metalloproteinase-9 (MMP-9) is a secreted glycoprotein with a major role in shaping the extracellular matrix and a detailed understanding of the secretory mechanism could help identify methods to correct diseases resulting from dysregulation of secretion. MMP-9 appears to follow a canonical secretory pathway through a quality control cycle in the endoplasmic reticulum (ER) before transport of the properly folded protein to the Golgi apparatus and beyond for secretion. Through a complementation assay, we determined that LMAN1, a well-studied lectin-carrier protein, interacts with a secretion-competent N-glycosylated MMP-9 in the ER while N-glycosylation-deficient secretion-compromised MMP-9 does not. In contrast, co-immunoprecipitation demonstrated protein interaction between LMAN1 and secretion-compromised N-glycosylation-deficient MMP-9. MMP-9 secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1. These observations support the role of LMAN1 as a lectin-carrier protein mediating efficient MMP-9 secretion." @default.
• W794091443 created "2016-06-24" @default.
• W794091443 creator A5006036283 @default.
• W794091443 creator A5024589429 @default.
• W794091443 creator A5048480770 @default.
• W794091443 creator A5083674413 @default.
• W794091443 date "2015-08-01" @default.
• W794091443 modified "2023-10-16" @default.
• W794091443 title "LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion" @default.
• W794091443 cites W1503628938 @default.
• W794091443 cites W1963051938 @default.
• W794091443 cites W1967055803 @default.
• W794091443 cites W1976669022 @default.
• W794091443 cites W1986274701 @default.
• W794091443 cites W2003652217 @default.
• W794091443 cites W2006690805 @default.
• W794091443 cites W2012340741 @default.
• W794091443 cites W2016859011 @default.
• W794091443 cites W2021153529 @default.
• W794091443 cites W2021427342 @default.
• W794091443 cites W2031211461 @default.
• W794091443 cites W2042027043 @default.
• W794091443 cites W2063736701 @default.
• W794091443 cites W2094372926 @default.
• W794091443 cites W2106770740 @default.
• W794091443 cites W2118325747 @default.
• W794091443 cites W2131963674 @default.
• W794091443 cites W2135998691 @default.
• W794091443 cites W2142329004 @default.
• W794091443 cites W2159410930 @default.
• W794091443 cites W2165534020 @default.
• W794091443 cites W2168055299 @default.
• W794091443 cites W2171129177 @default.
• W794091443 doi "https://doi.org/10.1016/j.bbrc.2015.06.164" @default.
• W794091443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4697752" @default.
• W794091443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26150355" @default.
• W794091443 hasPublicationYear "2015" @default.
• W794091443 type Work @default.
• W794091443 sameAs 794091443 @default.
• W794091443 citedByCount "20" @default.
• W794091443 countsByYear W7940914432015 @default.
• W794091443 countsByYear W7940914432018 @default.
• W794091443 countsByYear W7940914432019 @default.
• W794091443 countsByYear W7940914432020 @default.
• W794091443 countsByYear W7940914432021 @default.
• W794091443 countsByYear W7940914432022 @default.
• W794091443 countsByYear W7940914432023 @default.
• W794091443 crossrefType "journal-article" @default.
• W794091443 hasAuthorship W794091443A5006036283 @default.
• W794091443 hasAuthorship W794091443A5024589429 @default.
• W794091443 hasAuthorship W794091443A5048480770 @default.
• W794091443 hasAuthorship W794091443A5083674413 @default.
• W794091443 hasBestOaLocation W7940914432 @default.
• W794091443 hasConcept C104317684 @default.
• W794091443 hasConcept C108625454 @default.
• W794091443 hasConcept C109523444 @default.
• W794091443 hasConcept C115867849 @default.
• W794091443 hasConcept C119062480 @default.
• W794091443 hasConcept C143065580 @default.
• W794091443 hasConcept C156399914 @default.
• W794091443 hasConcept C158617107 @default.
• W794091443 hasConcept C188082640 @default.
• W794091443 hasConcept C2777313579 @default.
• W794091443 hasConcept C49039625 @default.
• W794091443 hasConcept C55493867 @default.
• W794091443 hasConcept C6492254 @default.
• W794091443 hasConcept C71829478 @default.
• W794091443 hasConcept C86803240 @default.
• W794091443 hasConcept C95444343 @default.
• W794091443 hasConceptScore W794091443C104317684 @default.
• W794091443 hasConceptScore W794091443C108625454 @default.
• W794091443 hasConceptScore W794091443C109523444 @default.
• W794091443 hasConceptScore W794091443C115867849 @default.
• W794091443 hasConceptScore W794091443C119062480 @default.
• W794091443 hasConceptScore W794091443C143065580 @default.
• W794091443 hasConceptScore W794091443C156399914 @default.
• W794091443 hasConceptScore W794091443C158617107 @default.
• W794091443 hasConceptScore W794091443C188082640 @default.
• W794091443 hasConceptScore W794091443C2777313579 @default.
• W794091443 hasConceptScore W794091443C49039625 @default.
• W794091443 hasConceptScore W794091443C55493867 @default.
• W794091443 hasConceptScore W794091443C6492254 @default.
• W794091443 hasConceptScore W794091443C71829478 @default.
• W794091443 hasConceptScore W794091443C86803240 @default.
• W794091443 hasConceptScore W794091443C95444343 @default.
• W794091443 hasFunder F4320332161 @default.
• W794091443 hasIssue "3" @default.
• W794091443 hasLocation W7940914431 @default.
• W794091443 hasLocation W7940914432 @default.
• W794091443 hasLocation W7940914433 @default.
• W794091443 hasLocation W7940914434 @default.
• W794091443 hasOpenAccess W794091443 @default.
• W794091443 hasPrimaryLocation W7940914431 @default.
• W794091443 hasRelatedWork W1573759787 @default.
• W794091443 hasRelatedWork W2065635384 @default.
• W794091443 hasRelatedWork W2075043312 @default.
• W794091443 hasRelatedWork W2138149238 @default.
• W794091443 hasRelatedWork W2141181686 @default.

• next