Matches in SemOpenAlex for { <https://semopenalex.org/work/W79429101> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W79429101 endingPage "8" @default.
- W79429101 startingPage "3" @default.
- W79429101 abstract "We have used ChIP-seq to map the distribution of two important histone H3 modifications, H3K4me2 and H3K27me3, over the whole genome at multiple time points during late mouse retina development. We merged these data with our previous retina developmental expression profiles and show that there are several epigenetic signatures specific for different functional groups of genes. The main conclusion from our study is that epigenetic signatures defined by H3K4me2 and H3K27me3 can distinguish cell-type specific genes from widespread transcripts and may be reflective of cell specificity during retina maturation. Rod photoreceptor-specific genes have a striking signature, a de novo accumulation of H3K4me2 and a complete absence of H3K27me3. We were able to use this signature in an unbiased search of the whole genome and identified essentially all the known rod photoreceptor genes as well as a group of novel genes that have a high probability of being rod photoreceptor specific. Comparison of our genome-wide chromatin signature maps with available data sets for Polymerase-II (Pol-II) and CRX binding sites and DNase1 Hypersensitive Sites (DHS) for retina shows great agreement. Because our approach is not dependent on high levels of gene expression, it provides a new way of identifying cell type-specific genes, particularly genes that may be involved in retinal diseases." @default.
- W79429101 created "2016-06-24" @default.
- W79429101 creator A5001481519 @default.
- W79429101 creator A5049332049 @default.
- W79429101 creator A5049865532 @default.
- W79429101 date "2014-01-01" @default.
- W79429101 modified "2023-09-25" @default.
- W79429101 title "Cell Type-Specific Epigenetic Signatures Accompany Late Stages of Mouse Retina Development" @default.
- W79429101 cites W1969080024 @default.
- W79429101 cites W1979015547 @default.
- W79429101 cites W1998267774 @default.
- W79429101 cites W2022756254 @default.
- W79429101 cites W2052063322 @default.
- W79429101 cites W2076483785 @default.
- W79429101 cites W2114715558 @default.
- W79429101 cites W2135423581 @default.
- W79429101 cites W2170466740 @default.
- W79429101 doi "https://doi.org/10.1007/978-1-4614-3209-8_1" @default.
- W79429101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24664674" @default.
- W79429101 hasPublicationYear "2014" @default.
- W79429101 type Work @default.
- W79429101 sameAs 79429101 @default.
- W79429101 citedByCount "10" @default.
- W79429101 countsByYear W794291012015 @default.
- W79429101 countsByYear W794291012016 @default.
- W79429101 countsByYear W794291012018 @default.
- W79429101 countsByYear W794291012019 @default.
- W79429101 countsByYear W794291012020 @default.
- W79429101 countsByYear W794291012023 @default.
- W79429101 crossrefType "book-chapter" @default.
- W79429101 hasAuthorship W79429101A5001481519 @default.
- W79429101 hasAuthorship W79429101A5049332049 @default.
- W79429101 hasAuthorship W79429101A5049865532 @default.
- W79429101 hasConcept C104317684 @default.
- W79429101 hasConcept C141231307 @default.
- W79429101 hasConcept C1491633281 @default.
- W79429101 hasConcept C150194340 @default.
- W79429101 hasConcept C169760540 @default.
- W79429101 hasConcept C189014844 @default.
- W79429101 hasConcept C2777093970 @default.
- W79429101 hasConcept C41091548 @default.
- W79429101 hasConcept C54355233 @default.
- W79429101 hasConcept C64927066 @default.
- W79429101 hasConcept C70721500 @default.
- W79429101 hasConcept C83640560 @default.
- W79429101 hasConcept C86803240 @default.
- W79429101 hasConceptScore W79429101C104317684 @default.
- W79429101 hasConceptScore W79429101C141231307 @default.
- W79429101 hasConceptScore W79429101C1491633281 @default.
- W79429101 hasConceptScore W79429101C150194340 @default.
- W79429101 hasConceptScore W79429101C169760540 @default.
- W79429101 hasConceptScore W79429101C189014844 @default.
- W79429101 hasConceptScore W79429101C2777093970 @default.
- W79429101 hasConceptScore W79429101C41091548 @default.
- W79429101 hasConceptScore W79429101C54355233 @default.
- W79429101 hasConceptScore W79429101C64927066 @default.
- W79429101 hasConceptScore W79429101C70721500 @default.
- W79429101 hasConceptScore W79429101C83640560 @default.
- W79429101 hasConceptScore W79429101C86803240 @default.
- W79429101 hasLocation W794291011 @default.
- W79429101 hasLocation W794291012 @default.
- W79429101 hasOpenAccess W79429101 @default.
- W79429101 hasPrimaryLocation W794291011 @default.
- W79429101 hasRelatedWork W2059789747 @default.
- W79429101 hasRelatedWork W2165200202 @default.
- W79429101 hasRelatedWork W2172833929 @default.
- W79429101 hasRelatedWork W2222447005 @default.
- W79429101 hasRelatedWork W2526262876 @default.
- W79429101 hasRelatedWork W2558699479 @default.
- W79429101 hasRelatedWork W2947477144 @default.
- W79429101 hasRelatedWork W3032827958 @default.
- W79429101 hasRelatedWork W3180707327 @default.
- W79429101 hasRelatedWork W4308625184 @default.
- W79429101 isParatext "false" @default.
- W79429101 isRetracted "false" @default.
- W79429101 magId "79429101" @default.
- W79429101 workType "book-chapter" @default.