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• W794313481 abstract "ABSTRACT Objectives : Cancer incidence is increasing in all countries and chemothera py-induced peripheral neuropathy (CIPN) in patients undergoing chemotherapeutic agent s have been a clinically serious problems. So far therapeutic options for CIPN patients are limited and no confirmed methods have yet been established for dealing with peripheral neuropathy. Th erefore this review is to provide an evidence-based summary of oriental medicine and CAM (complement ary and alternative medicine) neuroprotective and treatment therapies which have gone through clinical trials.Methods : An overview of the domestic and international papers of adult clinical trials relating management of only CIPN symptoms through 1990 to present were searched by electronic databases. Search key words were chemotherapy-induced neurotoxicity, chemo therapy-induced peripheral neuropathy, chemotherapy toxicity & herb, chemotherapy toxicity & acupunctu re, chemotherapy toxicity & CAM. Only English and Korean written papers were reviewed. Total 25 papers were reviewed in this study, 18 papers were retrieved by electronic search. Results : Clinical studies of managing CIPN were rare, two acupuncture clinical studies and four herb medicinal studies were found. Rest of 19 papers were about other CAM clinical studies. Total 25 papers were analyzed, and all interventions were focused on their pain control efficacy. Other 24 trials of potential therapies except one proved to be effective for CIPN, however some described to be inadequate positive or sufficient negative. Conclusions : As most of the studies were pilot studies, interventions for t he prevention and treatment of CIPN have to go through prospective confirmatory studies, such as larger scale randomized, double-blinded, placebo controlled clinical trials must be done for the safe an d effective use of proposed therapies. Also standard measurement scales have to be developed for the better clinical study of CIPN. Key words : Chemotherapy, Neurotoxicity, CIPN, Clinical trial, Oriental medicine, CAM" @default.
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• W794313481 date "2009-01-01" @default.
• W794313481 modified "2023-09-22" @default.
• W794313481 title "The Present Clinical Studies of Oriental Medicine and CAM Therapies in Chemotherapy-induced Peripheral Neurotoxicity" @default.
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