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- W79436021 abstract "Multiple sclerosis (MS), a frequent cause of neurological disease arising in early to middle adulthood, has a complex etiology involving both genetic and environmental factors. Recent years have witnessed great progress in the dissection of the fundamental genetic etiology underlying MS risk. To date, more than 100 variants that modulate disease susceptibility have been identified. The most important factor genome-wide resides in the major histocompatibility complex (MHC) region (odds ratio [OR] 3.1); the primary signal maps to the class II DR locus (primarily DRB1*1501) and a secondary signal maps to the A locus in the class 1 region. Other MS-associated variants are widely distributed across the genome and all have small effect (OR = 1.1–1.35); importantly, most cluster nearby genes known to affect immune function although as the MS genetic map expands some contribution of nervous system and vitamin D-associated pathways are also becoming evident. Taken together, a new genetic landscape of MS is now available for the research community that should help clarify the underlying biology of this disease and, hopefully, lead to new methods of treatment, early detection, and perhaps prevention." @default.
- W79436021 created "2016-06-24" @default.
- W79436021 creator A5014721690 @default.
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- W79436021 date "2015-01-01" @default.
- W79436021 modified "2023-10-16" @default.
- W79436021 title "Multiple Sclerosis" @default.
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- W79436021 doi "https://doi.org/10.1016/b978-0-12-410529-4.00085-1" @default.
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