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- W7946148 abstract "It was reported that a purified DNA-rich fraction, MY-1, extracted from Mycobacterium bovis Bacille Calmette Guerin BCG, exhibits a strong antitumor activity against various syngeneic mouse and guinea pig tumors by activating the host innate immune response (1,2). This fraction showed no direct cytotoxicity in vitro against these tumors. An intraperitoneal injection of MY-1 rendered mouse peritoneal cells strongly cytotoxic to YAC-1 cells in vitro, but not to P815 cells. This activity was destroyed by treatment with antiasialo-GM 1 antiserum, suggesting that the cells are natural killer (NK) cells. When mice were pretreated with antiasialo-GM1, MY-1 could not render the peritoneal cells cytotoxic. Antitumor activity of MY-1 was also abolished if the animals were pretreated with asialo-GM1 antiserum suggesting that the activity can be ascribed mainly to activated NK cells (3). MY-1 also augmented NK cell activity of mouse spleen cells in vitro, and produced factors which showed antiviral activity as interferon (IFN)-α/β and rendered macrophages cytotoxic towards tumor cells as IFN-γ (4). The activity reached the highest level after 6 h of incubation. A significant elevation of NK activity was seen after 1 h, while neither IFN α/β nor IFN γ was observed within 3 h." @default.
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- W7946148 date "2002-01-01" @default.
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- W7946148 title "Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human" @default.
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- W7946148 doi "https://doi.org/10.1007/978-1-59259-305-7_7" @default.
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