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- W79507296 abstract "The principal steroid hormones produced by placenta and fetal adrenal gland during primate pregnancy are estrogen, progesterone, and the glucocorticosteroids. These hormones are critical to preparation of the uterus for implantation early in gestation, the maintenance of pregnancy thereafter, and the development of a healthy newborn at term (reviewed in 1,2). For example, estrogen has a central integrative role in regulating key steps in the biosynthetic pathway for the formation of progesterone, a hormone essential to quiescence of the uterus and the maintenance of mammalian pregnancy. Progesterone, in turn, may have a role in immunosuppression to protect the developing conceptus from rejection by the maternal immune system. Estrogen and progesterone act in conjunction with prolactin, placental lactogen, and other hormones in development and preparation of the mammary gland for lactation. Estrogen also may stimulate utero-placental blood flow to provide nutrients and oxygen to the placenta and fetus for growth and development. Estrogen has been implicated in the cascade of events that initiate the process of labor. Finally, cortisol produced by the fetal adrenal gland has a critical role in the maturation of the lung and other organ systems in the developing fetus.KeywordsCorpus LuteumMetabolic Clearance RateCorticosteroid Binding GlobulinUteroplacental Blood FlowFetal Adrenal GlandThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W79507296 created "2016-06-24" @default.
- W79507296 creator A5057078720 @default.
- W79507296 creator A5060010329 @default.
- W79507296 date "1998-01-01" @default.
- W79507296 modified "2023-09-27" @default.
- W79507296 title "Secretion and Metabolism of Steroids in Primate Mammals During Pregnancy" @default.
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