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- W79509619 abstract "Activation of the complement system provides an important mechanism of defense of anorganism against invading pathogens. In the healthy individual this defense is finely regulatedto prevent attack of the complement system against cells and tissues of the host, however inabnormal situations this regulation can be out of balance. In the present thesis we look at amouse model where the classical pathway of complement, in conjunction with anti-C1qautoantibodies, is shown to be involved in the development of renal disease (Chapter 2). InChapter 3, a novel mouse model of complement-mediated glomerulonephritis is described.This model seems to be dependent on the alternative pathway of complement activation aswell as on Fc receptors, and provides a novel tool to dissect the contribution of differenteffector systems in renal inflammation.Then the natural complement-inhibitory properties of the defensin Human Neutrophil Peptide-1 and the extracellular matrix molecules decorin and biglycan are investigated, which are presented to play a role in the regulation of complement in vitro, which hopefully can beextended to in vivo situations of health and disease in the near future (Chapter 4 & 5). Thethesis is concluded with a general discussion in Chapter 6." @default.
- W79509619 created "2016-06-24" @default.
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- W79509619 date "2008-04-16" @default.
- W79509619 modified "2023-09-27" @default.
- W79509619 title "Complement and disease : activation and control" @default.
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