FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W795227272> ?p ?o ?g. }

• W795227272 endingPage "1242" @default.
• W795227272 startingPage "1235" @default.
• W795227272 abstract "Abstract Interferon γ (IFNγ) inhibits the growth and differentiation of highly purified human erythroid colony-forming cells (ECFCs) and induces erythroblast apoptosis. These effects are dose- and time-dependent. Because the cell surface receptor known as Fas (APO-1; CD95) triggers programmed cell death after activation by its ligand and because incubation of human ECFCs with IFNγ produces apoptosis, we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNγ in vitro. Only a small percentage of normal human ECFCs express Fas and this is present at a low level as detected by Northern blotting for the Fas mRNA and flow cytometric analysis of Fas protein using a specific mouse monoclonal antibody. The addition of IFNγ markedly increased the percentage of cells expressing Fas on the surface of the ECFCs as well as the intensity of Fas expression. Fas mRNA was increased by 6 hours, whereas Fas antigen on the cell surface increased by 24 hours, with a plateau at 72 hours. This increase correlated with the inhibitory effect of IFNγ on ECFC proliferation. CH-11 anti-Fas antibody, which mimics the action of the natural FasL, greatly enhanced IFNγ-mediated suppression of cell growth and production of apoptosis, indicating that Fas is functional. Expression of FasL was also demonstrated in normal ECFCs by reverse transcriptase-polymerase chain reaction and flow cytometric analysis with specific monoclonal antibody. FasL was constitutively expressed among erythroid progenitors as they matured from day 5 to day 8 and IFNγ treatment did not change this expression. Apoptosis induced by IFNγ was greatly reduced by the NOK-2 antihuman FasL antibody and an engineered soluble FasL receptor, Fas-Fc, suggesting that Fas-FasL interactions among the ECFCs produce the erythroid inhibitory effects and apoptosis initiated by IFNγ." @default.
• W795227272 created "2016-06-24" @default.
• W795227272 creator A5010933629 @default.
• W795227272 creator A5025544363 @default.
• W795227272 creator A5035001405 @default.
• W795227272 creator A5045985137 @default.
• W795227272 date "1998-02-15" @default.
• W795227272 modified "2023-10-13" @default.
• W795227272 title "Fas Ligand Is Present in Human Erythroid Colony-Forming Cells and Interacts With Fas Induced by Interferon γ to Produce Erythroid Cell Apoptosis" @default.
• W795227272 cites W1514099677 @default.
• W795227272 cites W1517945724 @default.
• W795227272 cites W1558473055 @default.
• W795227272 cites W1558828789 @default.
• W795227272 cites W182592261 @default.
• W795227272 cites W1836932878 @default.
• W795227272 cites W1970022901 @default.
• W795227272 cites W1972662519 @default.
• W795227272 cites W1973792489 @default.
• W795227272 cites W1984696190 @default.
• W795227272 cites W2002733542 @default.
• W795227272 cites W2013756895 @default.
• W795227272 cites W2016198585 @default.
• W795227272 cites W2044135934 @default.
• W795227272 cites W2045796964 @default.
• W795227272 cites W2047372273 @default.
• W795227272 cites W2049037545 @default.
• W795227272 cites W2050683184 @default.
• W795227272 cites W2052691929 @default.
• W795227272 cites W2054038727 @default.
• W795227272 cites W2075809552 @default.
• W795227272 cites W2086313080 @default.
• W795227272 cites W2107452159 @default.
• W795227272 cites W2109634867 @default.
• W795227272 cites W2114497161 @default.
• W795227272 cites W2116172091 @default.
• W795227272 cites W2135445366 @default.
• W795227272 cites W2137694849 @default.
• W795227272 cites W2143996326 @default.
• W795227272 cites W2164802863 @default.
• W795227272 cites W2168747001 @default.
• W795227272 cites W2207418296 @default.
• W795227272 cites W2301865658 @default.
• W795227272 cites W2464651370 @default.
• W795227272 cites W290394509 @default.
• W795227272 cites W3111558713 @default.
• W795227272 cites W4244374547 @default.
• W795227272 cites W4251877109 @default.
• W795227272 doi "https://doi.org/10.1182/blood.v91.4.1235" @default.
• W795227272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9454753" @default.
• W795227272 hasPublicationYear "1998" @default.
• W795227272 type Work @default.
• W795227272 sameAs 795227272 @default.
• W795227272 citedByCount "153" @default.
• W795227272 countsByYear W7952272722012 @default.
• W795227272 countsByYear W7952272722013 @default.
• W795227272 countsByYear W7952272722014 @default.
• W795227272 countsByYear W7952272722015 @default.
• W795227272 countsByYear W7952272722016 @default.
• W795227272 countsByYear W7952272722018 @default.
• W795227272 countsByYear W7952272722019 @default.
• W795227272 countsByYear W7952272722020 @default.
• W795227272 countsByYear W7952272722021 @default.
• W795227272 countsByYear W7952272722022 @default.
• W795227272 countsByYear W7952272722023 @default.
• W795227272 crossrefType "journal-article" @default.
• W795227272 hasAuthorship W795227272A5010933629 @default.
• W795227272 hasAuthorship W795227272A5025544363 @default.
• W795227272 hasAuthorship W795227272A5035001405 @default.
• W795227272 hasAuthorship W795227272A5045985137 @default.
• W795227272 hasBestOaLocation W7952272721 @default.
• W795227272 hasConcept C153911025 @default.
• W795227272 hasConcept C159654299 @default.
• W795227272 hasConcept C185592680 @default.
• W795227272 hasConcept C190283241 @default.
• W795227272 hasConcept C203014093 @default.
• W795227272 hasConcept C2776178377 @default.
• W795227272 hasConcept C3031857 @default.
• W795227272 hasConcept C31573885 @default.
• W795227272 hasConcept C542903549 @default.
• W795227272 hasConcept C553184892 @default.
• W795227272 hasConcept C55493867 @default.
• W795227272 hasConcept C66008609 @default.
• W795227272 hasConcept C86803240 @default.
• W795227272 hasConcept C95444343 @default.
• W795227272 hasConceptScore W795227272C153911025 @default.
• W795227272 hasConceptScore W795227272C159654299 @default.
• W795227272 hasConceptScore W795227272C185592680 @default.
• W795227272 hasConceptScore W795227272C190283241 @default.
• W795227272 hasConceptScore W795227272C203014093 @default.
• W795227272 hasConceptScore W795227272C2776178377 @default.
• W795227272 hasConceptScore W795227272C3031857 @default.
• W795227272 hasConceptScore W795227272C31573885 @default.
• W795227272 hasConceptScore W795227272C542903549 @default.
• W795227272 hasConceptScore W795227272C553184892 @default.
• W795227272 hasConceptScore W795227272C55493867 @default.
• W795227272 hasConceptScore W795227272C66008609 @default.
• W795227272 hasConceptScore W795227272C86803240 @default.
• W795227272 hasConceptScore W795227272C95444343 @default.

• next