Matches in SemOpenAlex for { <https://semopenalex.org/work/W795347788> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W795347788 abstract "Gastro-oesophageal reflux disease (GORD) has been implicated in the respiratory symptoms of CF. Studies in small populations suggest GORD may be present in up to 40% of these infants. Aim To describe the prevalence of GORD in a large cohort of infants with CF diagnosed by NBS. The secondary aim was to look for an association with bacterial infection. Methods Our NBS surveillance programme includes a 24 hr dual probe pH study and BAL for microbiology. Results were collected on infants over a 6 year period. GORD was diagnosed using ESPGHAN criteria: corrected reflux index (RI) >12%, reflux episodes >72, length of longest reflux episode >41 minutes. An association between GORD and positive bacterial samples was explored. Results Infants: n = 117, median age: 4.1 months (range 1.8–9.7 mo), 57 males (48%), 15 pancreatic insufficient (13%). 103 had valid pH studies (88%). RI >12% n = 44 (43%), reflux episodes >72 n = 55 (53%), reflux episodes >41 min n = 2. Positive bacteria at BAL = 29%. Including: PA = 3, SA = 8, HI = 5, coliforms = 7, other = 8 (some with mixed growths). There was no statistical difference in bacteria between those with and without GORD. There was a significant difference in wt z score −0.98 vs −0.2 p Discussion This large study confirms the high prevalence of GORD in infants with CF when using RI alone (43%), the true prevalence may be higher, 53% showed an abnormally high number of reflux episodes. No association with bacterial infection was found. In conclusion GORD appears more prevalent than thought in infants with CF and the significantly lower weight in this group needs further exploration." @default.
- W795347788 created "2016-06-24" @default.
- W795347788 creator A5000863980 @default.
- W795347788 creator A5038442044 @default.
- W795347788 creator A5046911959 @default.
- W795347788 creator A5068929859 @default.
- W795347788 creator A5070809307 @default.
- W795347788 date "2015-06-01" @default.
- W795347788 modified "2023-09-28" @default.
- W795347788 title "WS16.2 The prevalence of gastroesophageal reflux disease in infants with cystic fibrosis diagnosed by newborn screening and the relationship with lung infection" @default.
- W795347788 doi "https://doi.org/10.1016/s1569-1993(15)30091-6" @default.
- W795347788 hasPublicationYear "2015" @default.
- W795347788 type Work @default.
- W795347788 sameAs 795347788 @default.
- W795347788 citedByCount "0" @default.
- W795347788 crossrefType "journal-article" @default.
- W795347788 hasAuthorship W795347788A5000863980 @default.
- W795347788 hasAuthorship W795347788A5038442044 @default.
- W795347788 hasAuthorship W795347788A5046911959 @default.
- W795347788 hasAuthorship W795347788A5068929859 @default.
- W795347788 hasAuthorship W795347788A5070809307 @default.
- W795347788 hasBestOaLocation W7953477881 @default.
- W795347788 hasConcept C126322002 @default.
- W795347788 hasConcept C187212893 @default.
- W795347788 hasConcept C2776938444 @default.
- W795347788 hasConcept C2777714996 @default.
- W795347788 hasConcept C2779134260 @default.
- W795347788 hasConcept C43270747 @default.
- W795347788 hasConcept C71924100 @default.
- W795347788 hasConcept C72563966 @default.
- W795347788 hasConcept C90924648 @default.
- W795347788 hasConceptScore W795347788C126322002 @default.
- W795347788 hasConceptScore W795347788C187212893 @default.
- W795347788 hasConceptScore W795347788C2776938444 @default.
- W795347788 hasConceptScore W795347788C2777714996 @default.
- W795347788 hasConceptScore W795347788C2779134260 @default.
- W795347788 hasConceptScore W795347788C43270747 @default.
- W795347788 hasConceptScore W795347788C71924100 @default.
- W795347788 hasConceptScore W795347788C72563966 @default.
- W795347788 hasConceptScore W795347788C90924648 @default.
- W795347788 hasLocation W7953477881 @default.
- W795347788 hasOpenAccess W795347788 @default.
- W795347788 hasPrimaryLocation W7953477881 @default.
- W795347788 hasRelatedWork W1646149490 @default.
- W795347788 hasRelatedWork W1967657450 @default.
- W795347788 hasRelatedWork W2020032598 @default.
- W795347788 hasRelatedWork W2023246931 @default.
- W795347788 hasRelatedWork W2090949872 @default.
- W795347788 hasRelatedWork W2099752017 @default.
- W795347788 hasRelatedWork W2363985301 @default.
- W795347788 hasRelatedWork W2367427352 @default.
- W795347788 hasRelatedWork W2374182057 @default.
- W795347788 hasRelatedWork W2380056497 @default.
- W795347788 hasRelatedWork W2396243148 @default.
- W795347788 hasRelatedWork W2396957727 @default.
- W795347788 hasRelatedWork W2409360061 @default.
- W795347788 hasRelatedWork W2410687557 @default.
- W795347788 hasRelatedWork W2553268988 @default.
- W795347788 hasRelatedWork W2976646929 @default.
- W795347788 hasRelatedWork W2985542602 @default.
- W795347788 hasRelatedWork W3029651877 @default.
- W795347788 hasRelatedWork W3031318673 @default.
- W795347788 hasRelatedWork W965118510 @default.
- W795347788 isParatext "false" @default.
- W795347788 isRetracted "false" @default.
- W795347788 magId "795347788" @default.
- W795347788 workType "article" @default.