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• W795604554 abstract "EVIDENCE FOR ABSENCE OF LATCHBRIDGE FORMATION IN PHASIC SAPHENOUS ARTERY By Shaojie Han, B.M., M.M. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2005 Major Director: Paul H. Ratz Ph.D. Professor, Department of Biochemistry and Pediatrics Tonic arterial smooth muscle can produce strong contractions indefinitely by formation of slowly cycling crossbridges (latchbridges) that maintain force at a high energy economy. To fully understand the uniqueness of mechanisms regulating tonic arterial contraction, comparisons have been made to phasic visceral smooth muscles that do not sustain high forces. This study explored mechanisms of force maintenance in a phasic artery by comparing KC1-induced contractions in the tonic, femoral artery (FA) and its primary branch, the phasic saphenous artery (SA). KC1 rapidly (<I6 sec) caused strong increases in stress (1.2 x 10' ~ / m ~ ) and [ca2']i (250 nM) in FA and SA. By 10 min, [ca2+], declined to xi 175 nM in both tissues but stress was sustained in FA (1.3 x 1 o5 N/m2) and reduced by 40% in SA (0.8 x lo5 N/m2). Reduced tonic stress correlated with reduced myosin light chain (MLC) phosphorylation in SA (28% vs. 42% in FA). SA expressed more MLC phosphatase than FA, and permeabilized (p-escin) SA relaxed more rapidly than FA in the presence of MLC kinase blockade, suggesting that MLC phosphatase activity in SA was greater than that in FA. The reduction in MLC phosphorylation in SA was insufficient to account for reduced tonic force (latchbridge model), and SA expressed more fast myosin isoforms than did FA. Cytochalasin-D reduced force-maintenance more in FA than SA. These data support the hypothesis that strong force-maintenance is absent in SA because expressed motor proteins do not support latchbridge formation, and because actin polymerization is not stimulated. CHAPTER" @default.
• W795604554 created "2016-06-24" @default.
• W795604554 creator A5080651320 @default.
• W795604554 date "2005-01-01" @default.
• W795604554 modified "2023-09-23" @default.
• W795604554 title "Evidence for Absence of Latchbridge Formation in Phasic Saphenous Artery" @default.
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• W795604554 doi "https://doi.org/10.25772/vz4q-f378" @default.
• W795604554 hasPublicationYear "2005" @default.

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