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- W79564787 abstract "The purpose of the present study was to investigate the possible anti-oxidant effect(s) of Ambroxol on neutrophils activated by ligand-binding of the drug with membrane-associated adhesion integrin CD11a and to estimate dose-response changes in oxygen free radical production. The amount of free radical production by anti-CD11a- and anti-CD4-coated neutrophils stimulated with N-formyl-methionylleucyl-phenylalanine (FMLP) and challenged with increasing concentration of Ambroxol, was evaluated within a time frame of 90 minutes. A significant dose-dependent effect response of Ambroxol on O 2 − production by cells coated with anti-CD11a antibody was observed. This preliminary study opens a new perspective on the therapeutic role of Ambroxol as an antioxidant drug and for its potential use in controlling oxidative stress, particularly in leukocyte-dependent inflammation." @default.
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- W79564787 date "2013-10-01" @default.
- W79564787 modified "2023-09-24" @default.
- W79564787 title "Ambroxol Inhibits Neutrophil Respiratory Burst Activated by Alpha Chain Integrin Adhesion" @default.
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- W79564787 doi "https://doi.org/10.1177/039463201302600406" @default.
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