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- W79584 abstract "Dendritic abnormalities have been reported in both humans and animal models of epilepsy. Decreases in spine density and branching complexity have been observed. These observations appear paradoxical. Decreases in postsynaptic surface area suggest that neurons in the epileptic brain receive less excitatory synaptic input – and thus would be expected to be less excitable. However, patients and animals have epilepsy. This article discusses this paradox and suggests that the changes seen in dendritic structure may contribute to cognitive comorbidities. Potential mechanisms responsible for the structural abnormalities are discussed, as are new resources and techniques available to further the understanding of the underlying mechanisms and their consequences." @default.
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- W79584 date "2009-01-01" @default.
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- W79584 title "PLASTICITY | Dendritic Abnormalities in Epilepsy" @default.
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- W79584 doi "https://doi.org/10.1016/b978-012373961-2.00191-0" @default.
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