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- W79605433 abstract "The past few decades have seen the emergence of insulin/IGF-1-like signaling, target of rapamycin (TOR) signaling, sirtuins, and dietary restriction as important and evolutionarily conserved regulators of aging and longevity. Pharmacological agents that target components of these pathways, such as resveratrol and rapamycin, are being developed and tested for agingrelated activities in model organisms. This chapter deals with these models. Clinical trials for some of these agents are already under way for treatment of cancer and diabetes and will probably be expanded to other age-related disorders. These trials mark the first clinical benefits derived from comparative genetics of aging in model organisms. As key players in these conserved aging pathways continue to be uncovered and characterized using model systems, one also gain a better understanding of how they function and interact to integrate environmental signals into cellular responses that modulate aging. It has become apparent that, although longevity interventions can be mapped to genetically distinct pathways through epistasis and other types of studies, in reality most (or all) of these conserved longevity modifiers interact within cells as part of a complex network. For example, TOR activity both modulates and is modulated by insulin-like signaling, while DR alters signaling through both pathways. In future studies, it will be important to consider not only which proteins play a conserved longevity role, but which interactions between longevity factors have also been conserved. Such an approach should make it possible to develop a more comprehensive picture of the overarching longevity network and may resolve lingering questions and controversies in the field while providing more effective routes toward therapies for improving human health span and longevity." @default.
- W79605433 created "2016-06-24" @default.
- W79605433 creator A5064932278 @default.
- W79605433 creator A5072624010 @default.
- W79605433 date "2011-01-01" @default.
- W79605433 modified "2023-09-25" @default.
- W79605433 title "Comparative Genetics of Aging" @default.
- W79605433 cites W110392571 @default.
- W79605433 cites W1486595217 @default.
- W79605433 cites W1493922188 @default.
- W79605433 cites W1495019561 @default.
- W79605433 cites W1497810503 @default.
- W79605433 cites W1535702947 @default.
- W79605433 cites W1560262724 @default.
- W79605433 cites W1571291351 @default.
- W79605433 cites W1600394682 @default.
- W79605433 cites W1621906674 @default.
- W79605433 cites W1631908837 @default.
- W79605433 cites W1879890282 @default.
- W79605433 cites W1909120931 @default.
- W79605433 cites W1934941689 @default.
- W79605433 cites W1951075546 @default.
- W79605433 cites W1963578989 @default.
- W79605433 cites W1965414585 @default.
- W79605433 cites W1966089749 @default.
- W79605433 cites W1966132436 @default.
- W79605433 cites W1966145280 @default.
- W79605433 cites W1966262847 @default.
- W79605433 cites W1967083598 @default.
- W79605433 cites W1968051590 @default.
- W79605433 cites W1968446835 @default.
- W79605433 cites W1974890383 @default.
- W79605433 cites W1975060999 @default.
- W79605433 cites W1976416661 @default.
- W79605433 cites W1977144229 @default.
- W79605433 cites W1977466283 @default.
- W79605433 cites W1978383432 @default.
- W79605433 cites W1985244614 @default.
- W79605433 cites W1985308585 @default.
- W79605433 cites W1985425785 @default.
- W79605433 cites W1986039855 @default.
- W79605433 cites W1987240473 @default.
- W79605433 cites W1987738803 @default.
- W79605433 cites W1989398460 @default.
- W79605433 cites W1990769880 @default.
- W79605433 cites W1991052658 @default.
- W79605433 cites W1991080848 @default.
- W79605433 cites W1991087616 @default.
- W79605433 cites W1992049458 @default.
- W79605433 cites W1992663222 @default.
- W79605433 cites W1994305081 @default.
- W79605433 cites W1994357518 @default.
- W79605433 cites W1995384855 @default.
- W79605433 cites W1995869264 @default.
- W79605433 cites W1996395636 @default.
- W79605433 cites W1997145913 @default.
- W79605433 cites W1997408640 @default.
- W79605433 cites W2000731858 @default.
- W79605433 cites W2001133097 @default.
- W79605433 cites W2002622198 @default.
- W79605433 cites W2002741326 @default.
- W79605433 cites W2004002095 @default.
- W79605433 cites W2004607686 @default.
- W79605433 cites W2005029264 @default.
- W79605433 cites W2005867401 @default.
- W79605433 cites W2006022142 @default.
- W79605433 cites W2007711341 @default.
- W79605433 cites W2008371754 @default.
- W79605433 cites W2009332336 @default.
- W79605433 cites W2011153884 @default.
- W79605433 cites W2012753961 @default.
- W79605433 cites W2012956466 @default.
- W79605433 cites W2013342221 @default.
- W79605433 cites W2013463110 @default.
- W79605433 cites W2013742279 @default.
- W79605433 cites W2013749723 @default.
- W79605433 cites W2013937244 @default.
- W79605433 cites W2014892893 @default.
- W79605433 cites W2015214795 @default.
- W79605433 cites W2016106221 @default.
- W79605433 cites W2017117976 @default.
- W79605433 cites W2017147713 @default.
- W79605433 cites W2017525855 @default.
- W79605433 cites W2018359498 @default.
- W79605433 cites W2018659819 @default.
- W79605433 cites W2020266111 @default.
- W79605433 cites W2021432006 @default.
- W79605433 cites W2023431124 @default.
- W79605433 cites W2023448902 @default.
- W79605433 cites W2023973783 @default.
- W79605433 cites W2028193779 @default.
- W79605433 cites W2031143675 @default.
- W79605433 cites W2032462953 @default.
- W79605433 cites W2033815178 @default.
- W79605433 cites W2034103943 @default.
- W79605433 cites W2034661709 @default.
- W79605433 cites W2034734284 @default.
- W79605433 cites W2036813730 @default.