FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W7962941> ?p ?o ?g. }

• W7962941 endingPage "646" @default.
• W7962941 startingPage "640" @default.
• W7962941 abstract "Abstract The distinction between benign polyclonal and malignant monoclonal lymphoid disorders by morphology or immunophenotyping is frequently difficult. Therefore, the demonstration of clonal B-cell or T-cell populations by detecting identically rearranged immunoglobulin (Ig) or T-cell receptor (TCR) genes is often used to solve this diagnostic problem. Whereas the detection of rearranged Ig genes is well established, TCR gamma (γ) and beta (β) gene rearrangements often escape detection with the currently available polymerase chain reaction (PCR) assays. To establish a sensitive, specific, and rapid method for the detection of rearranged TCR-β genes, we developed a new PCR approach with family-specific Jβ primers and analyzed the resulting PCR products by high-resolution GeneScan technique. The superior efficiency of this new method was demonstrated by investigating 132 DNA samples extracted from lymph node and skin biopsy specimens (mostly formalin fixed) and blood samples of 62 patients who had a variety of T-cell lymphomas and leukemias. In all but 1 of the tumor samples (98.4%) a clonal amplificate was detectable after TCR-β PCR and the same clonal T-cell population was also found in 15 of 18 (83%) of the regional lymph nodes and in 7 of 11 (64%) of the peripheral blood samples. Direct comparison of these results with those obtained currently by the most widely applied TCR-γ PCR revealed an approximate 20% lower detection rate in the same set of samples than with the TCR-β PCR method. These results indicate that the new TCR-β PCR is most suitable for a rapid and reliable detection of clonal T-cell populations." @default.
• W7962941 created "2016-06-24" @default.
• W7962941 creator A5009323621 @default.
• W7962941 creator A5013410369 @default.
• W7962941 creator A5014442576 @default.
• W7962941 creator A5018491022 @default.
• W7962941 creator A5034016144 @default.
• W7962941 creator A5076386746 @default.
• W7962941 creator A5084273158 @default.
• W7962941 creator A5091740511 @default.
• W7962941 date "2000-07-15" @default.
• W7962941 modified "2023-10-03" @default.
• W7962941 title "High detection rate of T-cell receptor beta chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing" @default.
• W7962941 cites W1515219684 @default.
• W7962941 cites W1517855504 @default.
• W7962941 cites W1524489095 @default.
• W7962941 cites W1586561401 @default.
• W7962941 cites W1966455443 @default.
• W7962941 cites W1967591620 @default.
• W7962941 cites W1969669223 @default.
• W7962941 cites W1973190434 @default.
• W7962941 cites W1975164056 @default.
• W7962941 cites W1980168028 @default.
• W7962941 cites W1989261632 @default.
• W7962941 cites W1998374743 @default.
• W7962941 cites W2001729554 @default.
• W7962941 cites W2006654662 @default.
• W7962941 cites W2008262149 @default.
• W7962941 cites W2016899885 @default.
• W7962941 cites W2017776316 @default.
• W7962941 cites W2028460018 @default.
• W7962941 cites W2036571273 @default.
• W7962941 cites W2060165614 @default.
• W7962941 cites W2062601497 @default.
• W7962941 cites W2064487212 @default.
• W7962941 cites W2071867677 @default.
• W7962941 cites W2077163374 @default.
• W7962941 cites W2080634903 @default.
• W7962941 cites W2091590054 @default.
• W7962941 cites W2093096028 @default.
• W7962941 cites W2107202569 @default.
• W7962941 cites W2124313974 @default.
• W7962941 cites W2124314287 @default.
• W7962941 cites W2154433374 @default.
• W7962941 cites W2158854612 @default.
• W7962941 cites W2162924205 @default.
• W7962941 cites W2333865586 @default.
• W7962941 cites W2338997062 @default.
• W7962941 cites W2340502352 @default.
• W7962941 cites W2397942855 @default.
• W7962941 cites W2412720115 @default.
• W7962941 cites W3113140357 @default.
• W7962941 cites W3117197594 @default.
• W7962941 cites W4249932237 @default.
• W7962941 cites W4250889214 @default.
• W7962941 doi "https://doi.org/10.1182/blood.v96.2.640" @default.
• W7962941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10887129" @default.
• W7962941 hasPublicationYear "2000" @default.
• W7962941 type Work @default.
• W7962941 sameAs 7962941 @default.
• W7962941 citedByCount "98" @default.
• W7962941 countsByYear W79629412012 @default.
• W7962941 countsByYear W79629412013 @default.
• W7962941 countsByYear W79629412014 @default.
• W7962941 countsByYear W79629412015 @default.
• W7962941 countsByYear W79629412016 @default.
• W7962941 countsByYear W79629412017 @default.
• W7962941 countsByYear W79629412018 @default.
• W7962941 countsByYear W79629412019 @default.
• W7962941 countsByYear W79629412020 @default.
• W7962941 countsByYear W79629412021 @default.
• W7962941 countsByYear W79629412022 @default.
• W7962941 countsByYear W79629412023 @default.
• W7962941 crossrefType "journal-article" @default.
• W7962941 hasAuthorship W7962941A5009323621 @default.
• W7962941 hasAuthorship W7962941A5013410369 @default.
• W7962941 hasAuthorship W7962941A5014442576 @default.
• W7962941 hasAuthorship W7962941A5018491022 @default.
• W7962941 hasAuthorship W7962941A5034016144 @default.
• W7962941 hasAuthorship W7962941A5076386746 @default.
• W7962941 hasAuthorship W7962941A5084273158 @default.
• W7962941 hasAuthorship W7962941A5091740511 @default.
• W7962941 hasConcept C104317684 @default.
• W7962941 hasConcept C153911025 @default.
• W7962941 hasConcept C159654299 @default.
• W7962941 hasConcept C163864487 @default.
• W7962941 hasConcept C19317047 @default.
• W7962941 hasConcept C196166836 @default.
• W7962941 hasConcept C203014093 @default.
• W7962941 hasConcept C2776090121 @default.
• W7962941 hasConcept C2908647359 @default.
• W7962941 hasConcept C2992511266 @default.
• W7962941 hasConcept C49105822 @default.
• W7962941 hasConcept C542903549 @default.
• W7962941 hasConcept C54355233 @default.
• W7962941 hasConcept C553184892 @default.
• W7962941 hasConcept C71924100 @default.
• W7962941 hasConcept C86803240 @default.

• next