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- W79667933 abstract "Publisher SummaryCell activation in mixed lymphocyte cultures (MLC) is a result of lymphocyte activating determinants (LAD) as distinguished from serologically defined determinants (SD). In the mouse, there are two genetic systems that control the appearance of these determinants, one being located in the histocompatibility (H-2) complex and the other being controlled by the M-locus. The M-locus is not linked to H-2 or any known non-H-2 polymorphism and consists of four codominant determinants that are allelic and termed Mlsa, Mlsb, Mlsc and Mlsd. Several studies have shown that the product of the M-locus is present on murine B cells but not T cells. Evidence has also been presented for its presence on macrophages. This chapter presents some studies carried out to determine the ontogenetic development and organ distribution of the M-locus product on the surface of B lymphocytes of DBA/2N mice. It discusses the materials and methods used in these studies and reviews the results of these studies.The studies reflected a differential ontogenetic expression of the LAD responsible for stimulation across the M-locus as compared to those within the H-2 complex. The ontogenetic development of mature murine B lymphocytes begins with the appearance of kappa positive surface Ig. As maturation proceeds, B lymphocytes acquire an IgD-like surface Ig and the capacity to recognize and interact with complement components. Moreover, the studies showed that the surface antigens responsible for stimulation across the M-locus defined MLC, which initially are not detectable, are expressed on these developing B lymphocytes." @default.
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- W79667933 date "1976-01-01" @default.
- W79667933 modified "2023-09-26" @default.
- W79667933 title "FUNCTIONAL STUDIES OF THE ONTOGENY OF THE M-LOCUS PRODUCT: A SURFACE ANTIGEN OF MURINE B LYMPHOCYTES" @default.
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- W79667933 doi "https://doi.org/10.1016/b978-0-12-233750-5.50135-4" @default.
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