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- W796839948 abstract "Vascular trauma results in a number of system-wide consequences to the individual (due to blood loss and shock) and local consequences to tissue beds (due to ischemia as a result of disrupted perfusion). These changes—and the mitigation that good resuscitation and timely surgery can offer—govern the potential for both patient survival and functional recovery. A comprehensive understanding of the important intercellular and intracellular signalling pathways that mediate these effects may allow identification of modulators that will serve as future therapies. Ischemia-reperfusion injury is enacted at the endothelial level, with endothelial integrity further ameliorated or exacerbated by the chosen resuscitation strategy. In particular, the structural integrity of the glycocalyx appears central to these processes. Shock and ischemia combine, potentiate, and compound their individual effects such that the standard timelines for successful revascularization cannot be relied on to secure functional limb salvage. The time period before revascularization no longer guarantees that optimal recovery is shorter than previously understood and may be influenced by the quality of fluid resuscitation." @default.
- W796839948 created "2016-06-24" @default.
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- W796839948 date "2016-01-01" @default.
- W796839948 modified "2023-09-26" @default.
- W796839948 title "Pathophysiology of Vascular Trauma" @default.
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- W796839948 doi "https://doi.org/10.1016/b978-1-4557-1261-8.00004-7" @default.
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