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- W796862854 abstract "The absence of dystrophin caused by genetic disorders linked to the X chromosome is expressed in humans and dogs as a progressive and lethal disease characterized by weakness and muscle degeneration (1, 3). In skeletal muscle, injuries such as hypertrophy, atrophy, degeneration, necrosis and fibrosis are observed. Three Golden Retriever Muscular Dystrophy dogs (GRMD), from the kennel of the Associacao de Amigos dos Portadores de Distrofia Muscular AADM, Ribeirao Preto SP, Brazil, naturally died, aged four, six and 18 months were submitted to necropsy in Department of Veterinary Pathology of the Faculdade de Ciencias Agrarias e Veterinarias, Unesp, Jaboticabal, Brazil. The dogs presented, in the external inspection, very dry hair and muscular atrophy of the hind legs. In two animals we observed an increase in volume of bilateral hind limbs due to subcutaneous edema. In these, the necropsy showed subcutaneous edema (Fig. 1) and agenesis of the popliteal lymph nodes, indicative of lymphoedema. In the third animal (six month old) the popliteal lymph nodes were present and no edema was seen. In a study of hereditary ascendancy it was noted that all three dogs had the same paternal origin, and the breeding animal did not have these clinical features." @default.
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- W796862854 date "2010-05-01" @default.
- W796862854 modified "2023-10-01" @default.
- W796862854 title "Lymphoedema and agenesia of the popliteal lymph nodes in golden retriever dogs with muscular dystrophy (GRMD)" @default.
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