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- W797050036 abstract "Conclusions and summary ·Platelet adhesion onto immobilized fibrinogen under arterial flow conditions is mediated by integrin aIIbb3. ·This specific interaction is modulated by the HPA-1 polymorphism of the b-subunit of integrin aIIbb3. ·The HPA-1b/1b genotype is associated with an increased platelet adhesion. ·This increased adhesion of HPA-1b/1b platelets is already evident within 1 min following the interaction of platelets with immobilized fibrinogen. ·Specific platelet adhesion onto immobilized collagen is shear-rate dependent and time dependent and modulated through the a2b1 polymorphism (a2 807 C/T). ·Platelets with the a2 807TT-genotype showed significantly higher adhesion rates compared to platelets with the a2 807CC-genotype. ·After an initial platelet adhesion onto immobilized collagen, a further platelet adhesion (spreading and consecutive thrombus growth) is modulated through the HPA-1 polymorphism of the b-subunit of integrin aIIbb3. ·The critical “prothrombotic” genotype combination (HPA-1b/1b and a2 807TT genotypes) enhances platelet adhesion under arterial flow conditions, compared to “wildtype” variants of aIIbb3 and a2b1 (HPA-1a/1a and a2 807 CC genotype). Our data support the contention that genetically determined variants of platelet integrins aIIbb3 and a2b1 could play a role in arterial thrombogenesis and thus confirm the hypothesis derived from epidemiological studies. However, the risk attributable to only a single polymorphism in a complex disease such as stroke or myocardial infarction is probably low. Thus, a single polymorphism may have no clinical significance if evaluated independently, but specific combinations of common polymorphisms and the combination of related polymorphisms might play a relevant role in these diseases. In other words, the thrombotic effect of platelet receptor polymorphisms (single or combined) might be restricted to a combination with microenvironmental risk factors as demonstrated in our study. Understanding of the functional roles of platelet receptor polymorphism may increase our ability to further stratify patients according to their genetically determined thrombosis risk and may give us the opportunity to design and develop individually based therapeutic strategies in the prevention of arterial thrombosis." @default.
- W797050036 created "2016-06-24" @default.
- W797050036 creator A5082051161 @default.
- W797050036 date "2007-01-01" @default.
- W797050036 modified "2023-09-27" @default.
- W797050036 title "Functional relevance of HPA-1 and α2 807C/T platelet receptor polymorphisms under standardized in-vitro blood flow conditions" @default.
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