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- W79738298 abstract "A quantitative assay of RNA in the hepatocyte cytoplasm of puberal and impuberal animals after exposure to radiation was undertaken. Experiments were conducted on month-old (impuberal) and 3-month-old (puberal) mice, which were exposed to total-body radiation in a single dose of 100 R delivered from an RUM-11 unit. The results indicate that an increase in concentration of RNA in hepatocyte cytoplasm is observed in exposed month-old mice as compared to nonirradiated animals. The increase is significant, however, only at certain postradiation times (30 min, 1 and 4 h), whereas a significant decrease occurs 1 day after exposure. The area of hepatocyte cytoplasm of irradiated mice fluctuated over the control range. In irradiated 3-month-old mice, the RNA concentration increased significantly only 2 and 4 h after exposure, while the area of cytoplasm fluctuated over the normal range. Cytophotometry of hepatocytes revealed that there is an increase in RNA content in 3-month mice, as compared to month-old animals, as a result of increase in hepatocyte cytoplasm area. Exposure of month-old mice to radiation in a dosage of 100 R induces undulant changes in RNA content, whereas such changes are not demonstrable in 3-month mice, with the exception of 4 h after exposure.more » This is indicative of the greater radiosensitivity of month-old mice, as compared to animals that are 3 months old. (ERB)« less" @default.
- W79738298 created "2016-06-24" @default.
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- W79738298 date "1979-06-01" @default.
- W79738298 modified "2023-09-23" @default.
- W79738298 title "Quantitative changes in cytoplasmic RNA of hepatocytes in irradiated mice of different ages. [X rays]" @default.
- W79738298 hasPublicationYear "1979" @default.
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