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• W798727103 abstract "Dendritic cells currently represent a big focus of studies, because they’re primary targets of tumor activity on the immune system. The main objective of this study was to evaluate the relationship between the inflammatory infiltrate and dendritic cells (DCs) in mammary carcinomas simple type in female’s dogs. Two groups of mammary gland samples were formed, the first was composed of 18 mammary tissue samples unchanged (control group) and the second, with 26 mammary simple carcinomas (tumor group). In addition, 15 lymph nodes were analyzed from bitches with mammary gland tumor and four lymph nodes derived from bitches without mammary gland tumor. Immunodetection was performed to immature and mature myeloid DCs, plasmacytoid DCs, T cells, macrophages and molecules of the major histocompatibility complex class II (MHC -II). Mast cells have also been identified by the special staining toluidine blue. To lymph nodes, the immunodetection was performed only to immature and mature myeloid DCs. The average age of the bitches with mammary tumor was 9.3 years (30 %) and dogs without breed (SRD) were the most affected. No lymph node showed foci of micrometastases. From 17 bitches monitored for follow-up study, nine are alive and eight died. The cause of death more occurred was caused by metastasis (67%). In the mammary glands with tumor, it was observed that the mast cells and mature myeloid DCs appeared in peritumoral regions. The immature myeloid DCs, plasmacytoid DCs, macrophages and cells immunostained for MHC-II were seen only in the tumor stroma. The T cells were founded into the tumor and in peritumoral areas. Into the lymph nodes, the marking of immature myeloid DCs was concentrated in lymphoid follicles and paracortical zone; the mature DCs appeared only in the center of the lymphoid follicles. In mammary gland control, the number of inflammatory cells as well as DCs was minimal. Statistically significant difference was observed when the control group was compared with tumor group for immature myeloid DCs, mature myeloid DCs, plasmacytoid DCs and macrophages. As for T cells, mast cells and MHC-II, there was no statistical difference when compared tumor and control groups. The predominance of immature DCs in the tumor group is possibly related to an inefficient immune response, favoring the development and survival of tumor cells. The presence of plasmacytoid DCs in the same group would be indicative of a worse prognosis for female dogs with mammary tumors. Therefore, differentiation of dendritic cells could be influenced by canine tumor cells and the tumor microenvironment. These effects appear to extend to macrophages and T cells, which were also prevalent in tumor group. KEY-WORDS: dog, antigen presenting cells, immune evasion, immunohistochemistry, mammary tumor." @default.
• W798727103 created "2016-06-24" @default.
• W798727103 creator A5065451933 @default.
• W798727103 date "2013-10-10" @default.
• W798727103 modified "2023-09-26" @default.
• W798727103 title "Relação entre o infiltrado inflamatório e as células dendríticas na resposta imune aos carcinomas do tipo simples em mama de cadelas" @default.
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